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Aging and Dietary Restriction: The Yeast Paradigm

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Calorie Restriction, Aging and Longevity

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Abstract

The only intervention to have been consistently shown to extend the life span in organisms ranging from yeast to monkeys is calorie restriction (CR). Saccharomyces cerevisiae is perhaps the simplest among the major model organisms established for studies of calorie restriction and aging since it is unicellular, easily manipulated genetically, amenable to a number of powerful genome/proteome-wide screening techniques, and the genes that regulates its life span play similar roles in higher eukaryotes. Here we briefly review some of the methods and discoveries related to dietary restriction (DR) and aging in yeast and discuss the potential genes and mechanisms mediated its effect on life span.

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Authors and Affiliations

  1. Ethel Percy Andrus Gerontology Center, Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA

    Min Wei, Federica Madia & Valter D. Longo

  2. Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    Rafael de Cabo

Authors
  1. Min Wei
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  2. Federica Madia
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  3. Rafael de Cabo
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  4. Valter D. Longo
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Editor information

Editors and Affiliations

  1. Sydney, 2006, Australia

    Arthur V. Everitt

  2. University of Aarhus, University of Aarhus, Aarhus, 8000, Denmark

    Suresh I. S. Rattan

  3. Sydney, 2006, Australia

    David G. le Couteur

  4. National Institute on Aging, Gerontology Research Center, National Institute of Health, Nathan Shock Drive 5600, Baltimore, 21224, USA

    Rafael de Cabo

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Wei, M., Madia, F., de Cabo, R., Longo, V.D. (2010). Aging and Dietary Restriction: The Yeast Paradigm. In: Everitt, A., Rattan, S., le Couteur, D., de Cabo, R. (eds) Calorie Restriction, Aging and Longevity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8556-6_6

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