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Brain Protection in Schizophrenia, Mood and Cognitive Disorders pp 105–133Cite as

Vulnerability of the Brain to Neuropsychiatric Disorders Resulting from Abnormal Thyroid Hormone or Vitamin D Homeostasis

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Abstract

Nutritional modification is an approach to augment protection of the brain from psychiatric disease that is both inexpensive and with fewer side-effects than most psychoactive drugs. Two factors derived from nutritional sources that regulate gene transcription via nuclear receptors are thyroid hormone and vitamin D. Both of these factors thus lie at a nexus of environmental and genetic regulation of gene expression. Changes in both pathways have been associated with schizophrenia and depression but unlike dietary supplements such as omega-3 fatty acids, their mode of signalling is well understood. This chapter details the association of thyroid hormone and vitamin D with these psychiatric disorders. Likely targets for these two nuclear receptor regulators include the dopamine receptors, serotonergic pathways, hippocampal neurogenesis as well as components of the developing brain. The association of the nuclear receptor signalling pathways with several diseases suggests that they are less likely to be responsible for the unique features of each disease but are involved in aspects common to the disorders, as has been proposed for genes such as DISC1. An imbalance in the thyroid hormone and vitamin D pathways may contribute to depression and schizophrenia and restoration of homeostasis may provide a route by which the brain may be protected.

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Abbreviations

ATP:

Adenosine triphosphate

BDNF:

Brain derived neurotrophic factor

CNS:

Central nervous system

Cnr:

Cannabinoid receptor

CSF:

Cerebrospinal fluid

GABA:

Gamma-aminobutyric acid

GDNF:

Glial cell line derived neurotrophic factor

5-HT:

5-hydroxytryptamine

5HTT:

5-hydroxytryptamine transporter

5-HT1A:

5-hydroxytryptamine receptor 1A

N-CoR:

Nuclear receptor co-repressor

NGF:

Nerve growth factor

PI3K–PKB:

Phosphatidylinositide 3-kinase-protein kinase B

RA:

All-trans retinoic acid

SAD:

Seasonal affective disorder

Scn4b:

Sodium channel subunit

SMRT:

Silencing mediator for retinoid and thyroid hormone receptors

T4 :

Thyroxine

T3 :

Triiodothyronine

TH:

Thyroid hormone

TR:

Thyroid hormone receptor

TRH:

Thyrotropin-releasing hormone

TSH:

Thyroid stimulating hormone

TTR:

Transthyretin

VD:

Vitamin D

VDR:

Vitamin D receptor

References

  1. Mattson MP, Chan SL, Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev 2002; 82:637–672

    PubMed  CAS  Google Scholar 

  2. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev 2001; 81:1097–1142

    PubMed  CAS  Google Scholar 

  3. Bernal J, Gerald L. Thyroid Hormones and Brain Development Vitamins & Hormones. Academic Press; 2005:95–122

    Google Scholar 

  4. Kundu S, Roy S, De J, et al. Maintenance of homeostasis for thyroid hormone in the adult rat brain: possible involvement of a nuclear-mediated phenomenon. Neuroendocrinology 2007; 86:94–103

    Article  PubMed  CAS  Google Scholar 

  5. Abe T, Suzuki T, Unno M, et al. Thyroid hormone transporters: recent advances. Trends Endocrinol Metab 2002; 13:215–220

    Article  PubMed  CAS  Google Scholar 

  6. Salvatore D, Bartha T, Harney JW, et al. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 1996; 137:3308–3315

    Article  PubMed  CAS  Google Scholar 

  7. Bernal J. Action of thyroid hormone in brain. J Endocrinol Invest 2002; 25:268–288

    PubMed  CAS  Google Scholar 

  8. Campos-Barros A, Hoell T, Musa A, et al. Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system. J Clin Endocrinol Metab 1996; 81:2179–2185

    Article  PubMed  CAS  Google Scholar 

  9. Wu Y, Koenig RJ. Gene regulation by thyroid hormone. Trends Endocrinol Metabol 2000; 11:207–211

    Article  CAS  Google Scholar 

  10. Forrest D, Hallbook F, Persson H, et al. Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes. EMBO J 1991; 10:269–275

    PubMed  CAS  Google Scholar 

  11. Mellstrom B, Naranjo JR, Santos A, et al. Independent expression of the alpha and beta c-erbA genes in developing rat brain. Mol Endocrinol 1991; 5:1339–1350

    Article  PubMed  CAS  Google Scholar 

  12. Abel ED, Ahima RS, Boers ME, et al. Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons. J Clin Invest 2001; 107:1017–1023

    Article  PubMed  CAS  Google Scholar 

  13. Cook CB, Kakucska I, Lechan RM, et al. Expression of thyroid hormone receptor beta 2 in rat hypothalamus. Endocrinology 1992; 130:1077–1079

    Article  PubMed  CAS  Google Scholar 

  14. Royland JE, Parker JS, Gilbert ME. A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brain. J Neuroendocrinol 2008; 20: 1319–1338

    Article  PubMed  CAS  Google Scholar 

  15. Diez D, Grijota-Martinez C, Agretti P, et al. Thyroid hormone action in the adult brain: Gene expression profiling of the effects of single and multiple doses of Triiodo-L-thyronine in the rat striatum. Endocrinology 2008: en.2008-0350

    Google Scholar 

  16. Haas MJ, Mreyoud A, Fishman M, et al. Microarray analysis of thyroid hormone-induced changes in mRNA expression in the adult rat brain. Neurosci Lett 2004; 365:14–18

    Article  PubMed  CAS  Google Scholar 

  17. Leonard JL. Non-genomic actions of thyroid hormone in brain development. Steroids 2008; 73:1008–1012

    Article  PubMed  CAS  Google Scholar 

  18. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocrine Rev 2008; 29:76–131

    Article  CAS  Google Scholar 

  19. Ganguli M, Burmeister LA, Seaberg EC, et al. Association between dementia and elevated TSH: a community-based study. Biol Psychiatry 1996; 40:714–725

    Article  PubMed  CAS  Google Scholar 

  20. van Osch LADM, Hogervorst E, Combrinck M, et al. Low thyroid-stimulating hormone as an independent risk factor for Alzheimer disease. Neurology 2004; 62:1967–1971

    Article  PubMed  CAS  Google Scholar 

  21. Squizzato A, Gerdes VEA, Brandjes DPM, et al. Thyroid diseases and cerebrovascular disease. Stroke 2005; 36:2302–2310

    Article  PubMed  CAS  Google Scholar 

  22. Bauer M, Goetz T, Glenn T, et al. The thyroid-brain interaction in thyroid disorders and mood disorders. J Neuroendocrinol 2008; 20:1101–1114

    Article  PubMed  CAS  Google Scholar 

  23. Norman AW. Vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006; 147:5542–5548

    Article  PubMed  CAS  Google Scholar 

  24. Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1[alpha]-hydroxylase in human brain. J Chem Neuroanatomy 2005; 29:21–30

    Article  CAS  Google Scholar 

  25. Stumpf WE, O’Brien LP. 1,25(OH)2 vitamin D3 sites of action in the brain. An autoradiographic study. Histochemistry 1987; 87:393–406

    Article  PubMed  CAS  Google Scholar 

  26. Prüfer K, Veenstra TD, Jirikowski GF, et al. Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J Chem Neuroanatomy 1999; 16:135–145

    Article  Google Scholar 

  27. Musiol IM, Stumpf WE, Bidmon HJ, et al. Vitamin D nuclear binding to neurons of the septal, substriatal and amygdaloid area in the siberian hamster (Phodopus sungorus) brain. Neuroscience 1992; 48:841–848

    Article  PubMed  CAS  Google Scholar 

  28. Veenstra TD, Prüfer K, Koenigsberger C, et al. 1,25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo. Brain Res 1998; 804:193–205

    Article  PubMed  CAS  Google Scholar 

  29. Garcion E, Wion-Barbot N, Montero-Menei CN, et al. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 2002; 13:100–105

    Article  PubMed  CAS  Google Scholar 

  30. Cantorna MT, Zhu Y, Froicu M, et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004; 80:1717S–1720S

    PubMed  CAS  Google Scholar 

  31. Brewer LD, Thibault V, Chen K-C, et al. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci 2001; 21:98–108

    PubMed  CAS  Google Scholar 

  32. Brewer LD, Porter NM, Kerr DS, et al. Chronic 1[alpha],25-(OH)2vitamin D3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging. Cell Calcium 2006; 40:277–286

    Article  PubMed  CAS  Google Scholar 

  33. de Viragh PA, Haglid KG, Celio MR. Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis. Proc Natl Acad Sci 1989; 86:3887–3890

    Article  PubMed  Google Scholar 

  34. Neveu I, Naveilhan P, Baudet C, et al. 1,25-dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport 1994; 6:124–126

    Article  PubMed  CAS  Google Scholar 

  35. Neveu I, Naveilhan P, Jehan F, et al. 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res 1994; 24: 70–76

    Article  PubMed  CAS  Google Scholar 

  36. Baas D, Prüfer K, Ittel ME, et al. Rat oligodendrocytes express the vitamin D3 receptor and respond to 1,25-dihydroxyvitamin D3. Glia 2000; 31:59–68

    Article  PubMed  CAS  Google Scholar 

  37. Norman AW, Bouillon R, Whiting SJ, et al. 13th Workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 2007; 103:204–205

    Article  PubMed  CAS  Google Scholar 

  38. Kalueff AV, Minasyan A, Tuohimaa P. Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Res Bull 2005; 67:156–160

    Article  PubMed  CAS  Google Scholar 

  39. Janjoppi L, Katayama MH, Scorza FA, et al. Expression of vitamin D receptor mRNA in the hippocampal formation of rats submitted to a model of temporal lobe epilepsy induced by pilocarpine. Brain Res Bulletin 2008; 76:480–484

    Article  CAS  Google Scholar 

  40. Przybelski RJ, Binkley NC. Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Archiv Biochem Biophys 2007; 460:202–205

    Article  CAS  Google Scholar 

  41. Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: Preventing “D”ecline? Mol Aspects Med 2008; 29:415–422

    Article  PubMed  CAS  Google Scholar 

  42. Smolders J, Damoiseaux J, Menheere P, et al. Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol 2008; 194:7–17

    Article  PubMed  CAS  Google Scholar 

  43. DeLisi LE, Boccio AM, Riordan H, et al. Familial thyroid disease and delayed language development in first admission patients with schizophrenia. Psychiatry Res 1991; 38:39–50

    Article  PubMed  CAS  Google Scholar 

  44. Feng J, Yan J, Michaud S, et al. Scanning of estrogen receptor alpha (ERalpha) and thyroid hormone receptor alpha (TRalpha) genes in patients with psychiatric diseases: four missense mutations identified in ERalpha gene. Am J Med Genet 2001; 105:369–374

    Article  PubMed  CAS  Google Scholar 

  45. Ruano D, Macedo A, Soares MJ, et al. Transthyretin: no association between serum levels or gene variants and schizophrenia. J Psychiatr Res 2007; 41:667–672

    Article  PubMed  Google Scholar 

  46. Heinrich TW, Grahm G. Hypothyroidism presenting as psychosis: myxedema madness revisited. Prim Care Companion J Clin Psychiatry 2003; 5:260–266

    Article  PubMed  Google Scholar 

  47. Reus VI. Behavioral disturbances associated with endocrine disorders. Annu Rev Med 1986; 37:205–214

    Article  PubMed  CAS  Google Scholar 

  48. Brownlie BE, Rae AM, Walshe JW, et al. Psychoses associated with thyrotoxicosis – ‘thyrotoxic psychosis.’ A report of 18 cases, with statistical analysis of incidence. Eur J Endocrinol 2000; 142:438–444

    Article  PubMed  CAS  Google Scholar 

  49. Bremner JD, McCaffery P. The neurobiology of retinoic acid in affective disorders. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:315–331

    Article  PubMed  CAS  Google Scholar 

  50. MacSweeney D, Timms P, Johnson A. Thryo-endocrine pathology, obstetric morbidity and schizophrenia: survey of a hundred families with a schizophrenic proband. Psychol Med 1978; 8:151–155

    Article  PubMed  CAS  Google Scholar 

  51. Baumgartner A, Hahnenkamp L, Meinhold H. Effects of age and diagnosis on thyrotropin response to thyrotropin-releasing hormone in psychiatric patients. Psychiatry Res 1986; 17:285–294

    Article  PubMed  CAS  Google Scholar 

  52. Morley JE, Shafer RB. Thyroid function screening in new psychiatric admissions. Arch Intern Med 1982; 142:591–593

    Article  PubMed  CAS  Google Scholar 

  53. Langer G, Resch F, Aschauer H, et al. TSH-response patterns to TRH stimulation may indicate therapeutic mechanisms of antidepressant and neuroleptic drugs. Neuropsychobiology 1984; 11:213–218

    Article  PubMed  CAS  Google Scholar 

  54. Beasley CM, Jr., Magnusson M, Garver DL. TSH response to TRH and haloperidol response latency in psychoses. Biol Psychiatry 1988; 24:423–431

    Article  PubMed  CAS  Google Scholar 

  55. Roca RP, Blackman MR, Ackerley MB, et al. Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism. Endocr Res 1990; 16:415–447

    Article  PubMed  CAS  Google Scholar 

  56. Yazici K, Yazici AE, Taneli B. Different neuroendocrine profiles of remitted and nonremitted schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:579–584

    Article  PubMed  CAS  Google Scholar 

  57. Baumgartner A, Pietzcker A, Gaebel W. The hypothalamic-pituitary-thyroid axis in patients with schizophrenia. Schizophr Res 2000; 44:233–243

    Article  PubMed  CAS  Google Scholar 

  58. Ryan WG, Roddam RF, Grizzle WE. Thyroid function screening in newly admitted psychiatric inpatients. Ann Clin Psychiatry 1994; 6:7–12

    Article  PubMed  CAS  Google Scholar 

  59. Hofmann P, Gangadhar BN, Probst C, et al. TSH response to TRH and ECT. J Affect Disord 1994; 32:127–131

    Article  PubMed  CAS  Google Scholar 

  60. Sim K, Chong SA, Chan YH, et al. Thyroid dysfunction in chronic schizophrenia within a state psychiatric hospital. Ann Acad Med Singapore 2002; 31:641–644

    PubMed  CAS  Google Scholar 

  61. Othman SS, Abdul Kadir K, Hassan J, et al. High prevalence of thyroid function test abnormalities in chronic schizophrenia. Aust N Z J Psychiatry 1994; 28:620–624

    Article  PubMed  CAS  Google Scholar 

  62. Paunovic VR, Timotijevic I, Marinkovic D. Neuroleptic actions on the thyroid axis: different effects of clozapine and haloperidol. Int Clin Psychopharmacol 1991; 6:133–139

    Article  PubMed  CAS  Google Scholar 

  63. Rao ML, Gross G, Strebel B, et al. Serum amino acids, central monoamines, and hormones in drug-naive, drug-free, and neuroleptic-treated schizophrenic patients and healthy subjects. Psychiatry Res 1990; 34:243–257

    Article  PubMed  CAS  Google Scholar 

  64. Kaiser S, Foltz LA, George CA, et al. Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia. Neurobiol Dis 2004; 16:220–235

    Article  PubMed  CAS  Google Scholar 

  65. Lexow N, Joyce JN, Kim SJ, et al. Alterations in TRH receptors in temporal lobe of schizophrenics: a quantitative autoradiographic study. Synapse 1994; 18:315–327

    Article  PubMed  CAS  Google Scholar 

  66. Nillni EA, Sevarino KA. The biology of pro-thyrotropin-releasing hormone-derived peptides. Endocr Rev 1999; 20:599–648

    Article  PubMed  CAS  Google Scholar 

  67. Hermann D, Hewer W, Lederbogen F. Testing the association between thyroid dysfunction and psychiatric diagnostic group in an iodine-deficient area. J Psychiatry Neurosci 2004; 29:444–449

    PubMed  Google Scholar 

  68. Clark ML, Paredes A, Costiloe JP, et al. Synthetic thyroid releasing hormone (TRH) administered orally to chronic schizophrenic patients. Psychopharmacol Commun 1975; 1:191–200

    PubMed  CAS  Google Scholar 

  69. Kobayashi K, Nakaoka K, Tsuji H, et al. Effects of thyrotropin-releasing hormone in chronic schizophrenic patients. Acta Med Okayama 1980; 34:263–273

    PubMed  CAS  Google Scholar 

  70. Palha JA, Goodman AB. Thyroid hormones and retinoids: a possible link between genes and environment in schizophrenia. Brain Res Rev 2006; 51:61–71

    Article  PubMed  CAS  Google Scholar 

  71. Toda M, Abi-Dargham A. Dopamine hypothesis of schizophrenia: making sense of it all. Curr Psychiatry Rep 2007; 9:329–336

    Article  PubMed  Google Scholar 

  72. Crocker AD, Overstreet DH. Modification of the behavioural effects of haloperidol and of dopamine receptor regulation by altered thyroid status. Psychopharmacology (Berl) 1984; 82:102–106

    Article  CAS  Google Scholar 

  73. Crocker AD, Overstreet DH, Crocker JM. Hypothyroidism leads to increased dopamine receptor sensitivity and concentration. Pharmacol Biochem Behav 1986; 24:1593–1597

    Article  PubMed  CAS  Google Scholar 

  74. Cameron DL, Crocker AD. The hypothyroid rat as a model of increased sensitivity to dopamine receptor agonists. Pharmacol Biochem Behav 1990; 37:627–632

    Article  PubMed  CAS  Google Scholar 

  75. Davis KL, Stewart DG, Friedman JI, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 2003; 60:443–456

    Article  PubMed  Google Scholar 

  76. Walterfang M, Wood SJ, Velakoulis D, et al. Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia. Neurosci Biobehav Rev 2006; 30:918–948

    Article  PubMed  Google Scholar 

  77. Rodriguez-Pena A. Oligodendrocyte development and thyroid hormone. J Neurobiol 1999; 40:497–512

    Article  PubMed  CAS  Google Scholar 

  78. Moskovitz RA. Seasonality in schizophrenia. Lancet 1978; 1:664

    Google Scholar 

  79. McGrath J. Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophr Res 1999; 40:173–177

    Article  PubMed  CAS  Google Scholar 

  80. Bodnar LM, Simhan HN, Powers RW, et al. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 2007; 137:447–452

    PubMed  CAS  Google Scholar 

  81. O’Hare A, Walsh D, Torrey F. Seasonality of schizophrenic births in Ireland. Br J Psychiatry 1980; 137:74–77

    Article  PubMed  Google Scholar 

  82. Torrey EF, Miller J, Rawlings R, et al. Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 1997; 28:1–38

    Article  PubMed  CAS  Google Scholar 

  83. Battle YL, Martin BC, Dorfman JH, et al. Seasonality and infectious disease in schizophrenia: the birth hypothesis revisited. J Psychiatr Res 1999; 33:501–509

    Article  PubMed  CAS  Google Scholar 

  84. Harrison G. Searching for the causes of schizophrenia: the role of migrant studies. Schizophr Bull 1990; 16:663–671

    Article  PubMed  CAS  Google Scholar 

  85. Selten JP, Slaets J, Kahn R. Prenatal exposure to influenza and schizophrenia in Surinamese and Dutch Antillean immigrants to The Netherlands. Schizophr Res 1998; 30:101–103

    Article  PubMed  CAS  Google Scholar 

  86. Marcelis M, Navarro-Mateu F, Murray R, et al. Urbanization and psychosis: a study of 1942–1978 birth cohorts in The Netherlands. Psychol Med 1998; 28:871–879

    Article  PubMed  CAS  Google Scholar 

  87. Mortensen PB, Pedersen CB, Westergaard T, et al. Effects of family history and place and season of birth on the risk of schizophrenia. N Engl J Med 1999; 340:603–608

    Article  PubMed  CAS  Google Scholar 

  88. Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 1995; 61:638S–645S

    PubMed  CAS  Google Scholar 

  89. Hafner H, Haas S, Pfeifer-Kurda M, et al. Abnormal seasonality of schizophrenic births. A specific finding? Eur Arch Psychiatry Neurol Sci 1987; 236:333–342

    Article  PubMed  CAS  Google Scholar 

  90. Kendell RE, Adams W. Exposure to sunlight, vitamin D and schizophrenia. Schizophr Res 2002; 54:193–198

    Article  PubMed  CAS  Google Scholar 

  91. Selten JP, Veen N, Feller W, et al. Incidence of psychotic disorders in immigrant groups to The Netherlands. Br J Psychiatry 2001; 178:367–372

    Article  PubMed  CAS  Google Scholar 

  92. Feron F, Burne TH, Brown J, et al. Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Res Bull 2005; 65:141–148

    Article  PubMed  CAS  Google Scholar 

  93. Almeras L, Eyles D, Benech P, et al. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics 2007; 7:769–780

    Article  PubMed  CAS  Google Scholar 

  94. Eyles D, Almeras L, Benech P, et al. Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J Steroid Biochem Mol Biol 2007; 103:538–545

    Article  PubMed  CAS  Google Scholar 

  95. Kalkman HO. The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia. Pharmacol Ther 2006; 110:117–134

    Article  PubMed  CAS  Google Scholar 

  96. Hmama Z, Nandan D, Sly L, et al. 1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex. J Exp Med 1999; 190:1583–1594

    Article  PubMed  CAS  Google Scholar 

  97. Reynolds GP, Abdul-Monim Z, Neill JC, et al. Calcium binding protein markers of GABA deficits in schizophrenia – postmortem studies and animal models. Neurotox Res 2004; 6:57–61

    Article  PubMed  Google Scholar 

  98. Li YC, Pirro AE, Demay MB. Analysis of vitamin D-dependent calcium-binding protein messenger ribonucleic acid expression in mice lacking the vitamin D receptor. Endocrinology 1998; 139:847–851

    Article  PubMed  CAS  Google Scholar 

  99. Becker A, Eyles DW, McGrath JJ, et al. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res 2005; 161:306–312

    Article  PubMed  CAS  Google Scholar 

  100. Becker A, Grecksch G. Pharmacological treatment to augment hole board habituation in prenatal Vitamin D-deficient rats. Behav Brain Res 2006; 166:177–183

    Article  PubMed  CAS  Google Scholar 

  101. O’Loan J, Eyles DW, Kesby J, et al. Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology 2007; 32:227–234

    Article  PubMed  CAS  Google Scholar 

  102. Harms LR, Eyles DW, McGrath JJ, et al. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6 J mice. Behav Brain Res 2008; 187:343–350

    Article  PubMed  CAS  Google Scholar 

  103. Eyles DW, Rogers F, Buller K, et al. Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function. Psychoneuroendocrinology 2006; 31:958–964

    Article  PubMed  CAS  Google Scholar 

  104. Minasyan A, Keisala T, Lou YR, et al. Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 2007; 104:274–280

    Article  PubMed  CAS  Google Scholar 

  105. Kalueff AV, Lou YR, Laaksi I, et al. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport 2004; 15:1271–1274

    Article  PubMed  CAS  Google Scholar 

  106. Burne TH, Johnston AN, McGrath JJ, et al. Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res Bull 2006; 69:74–78

    Article  PubMed  CAS  Google Scholar 

  107. Ozer S, Ulusahin A, Ulusoy S, et al. Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28:255–266

    Article  PubMed  CAS  Google Scholar 

  108. Labuda M, Fujiwara TM, Ross MV, et al. Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q13–14. J Bone Miner Res 1992; 7:1447–1453

    Article  PubMed  CAS  Google Scholar 

  109. Yan J, Feng J, Craddock N, et al. Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Neurosci Lett 2005; 380:37–41

    Article  PubMed  CAS  Google Scholar 

  110. Handoko HY, Nancarrow DJ, Mowry BJ, et al. Polymorphisms in the vitamin D receptor and their associations with risk of schizophrenia and selected anthropometric measures. Am J Hum Biol 2006; 18:415–417

    Article  PubMed  CAS  Google Scholar 

  111. Bauer M, Whybrow PC. Thyroid hormone, neural tissue and mood modulation. World J Biol Psychiatry 2001; 2:59–69

    Article  PubMed  CAS  Google Scholar 

  112. Kirkegaard C, Faber J. The role of thyroid hormones in depression. Eur J Endocrinol 1998; 138:1–9

    Article  PubMed  CAS  Google Scholar 

  113. Musselman DL, Nemeroff CB. Depression and endocrine disorders: focus on the thyroid and adrenal system. Br J Psychiatry Suppl 1996:123–128

    Google Scholar 

  114. Fliers E, Alkemade A, Wiersinga WM, et al. Hypothalamic thyroid hormone feedback in health and disease. Prog Brain Res 2006; 153:189–207

    Article  PubMed  CAS  Google Scholar 

  115. Henley W, Koehnle T. Thyroid hormones and the treatment of depression: An examination of basic hormonal actions in the mature mammalian brain. Synapse 1997; 27:36–44

    Article  PubMed  CAS  Google Scholar 

  116. Joffe RT, Sokolov ST. Thyroid hormone treatment of primary unipolar depression: a review. Int J Neuropsychopharmacol 2000; 3:143–147

    Article  PubMed  CAS  Google Scholar 

  117. Haggerty JJ, Prange AJ. Borderline hypothyroidism and depression. Ann Rev Med 1995; 46:37

    Article  PubMed  CAS  Google Scholar 

  118. Bauer M, Heinz A, Whybrow PC. Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain. Mol Psychiatry 2002; 7:140–156

    Article  PubMed  CAS  Google Scholar 

  119. Lifschytz T, Segman R, Shalom G, et al. Basic mechanisms of augmentation of antidepressant effects with thyroid hormone. Curr Drug Targets 2006; 7:203–210

    Article  PubMed  CAS  Google Scholar 

  120. Mason GA, Bondy SC, Nemeroff CB, et al. The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. Psychoneuroendocrinology 1987; 12:261–270

    Article  PubMed  CAS  Google Scholar 

  121. Sandrini M, Vitale G, Vergoni AV, et al. Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life Sci 1996; 58:1551–1559

    Article  PubMed  CAS  Google Scholar 

  122. Swann AC. Thyroid hormone and norepinephrine: effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart. J Neural Transm 1988; 71:195–205

    Article  PubMed  CAS  Google Scholar 

  123. Constantinou C, Margarity M, Valcana T. Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Mol Cell Biochem 2005; 278:93–100

    Article  PubMed  CAS  Google Scholar 

  124. Venero C, Guadano-Ferraz A, Herrero AI, et al. Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment. Genes Dev 2005; 19:2152–2163

    Article  PubMed  CAS  Google Scholar 

  125. Hettema JM. What is the genetic relationship between anxiety and depression? Am J Med Genet Part C: Seminars Medical Genet 2008; 148C:140–146

    Article  Google Scholar 

  126. Kulikov A, Torresani J, Jeanningros R. Experimental hypothyroidism increases immobility in rats in the forced swim paradigm. Neurosci Lett 1997; 234:111–114

    Article  PubMed  CAS  Google Scholar 

  127. Kulikov A, Moreau X, Jeanningros R. Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain1. Neuroendocrinology 1999; 69:453–459

    Article  PubMed  CAS  Google Scholar 

  128. Singhal RL, Rastogi RB, Hrdina PD. Brain biogenic amines and altered thyroid function. Life Sci 1975; 17:1617–1626

    Article  PubMed  CAS  Google Scholar 

  129. Vaccari A. Decreased central serotonin function in hypothyroidism. Eur J Pharmacol 1982; 82:93–95

    Article  PubMed  CAS  Google Scholar 

  130. Atterwill CK. Effect of acute and chronic tri-iodothyronine (T3) administration to rats on central 5-HT and dopamine-mediated behavioural responses and related brain biochemistry. Neuropharmacology 1981; 20:131–144

    Article  PubMed  CAS  Google Scholar 

  131. Brochet D, Martin P, Soubrie P, et al. Effects of triiodothyronine on the 5-hydroxytryptophan-induced head twitch and its potentiation by antidepressants in mice. Eur J Pharmacol 1985; 112:411–414

    Article  PubMed  CAS  Google Scholar 

  132. Ambrogini P, Cuppini R, Ferri P, et al. Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 2005; 81:244–253

    Article  PubMed  CAS  Google Scholar 

  133. Desouza LA, Ladiwala U, Daniel SM, et al. Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Mol Cell Neurosci 2005; 29:414–426

    Article  PubMed  CAS  Google Scholar 

  134. Fernandez M, Pirondi S, Manservigi M, et al. Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Eur J Neurosci 2004; 20:2059–2070

    Article  PubMed  CAS  Google Scholar 

  135. Lemkine GF, Raj A, Alfama G, et al. Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor. FASEB J 2005; 19:863–865

    PubMed  CAS  Google Scholar 

  136. Montero-Pedrazuela A, Venero C, Lavado-Autric R, et al. Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior. Mol Psychiatry 2006; 11:361–371

    Article  PubMed  CAS  Google Scholar 

  137. Kempermann G, Krebs J, Fabel K. The contribution of failing adult hippocampal neurogenesis to psychiatric disorders. Curr Opin Psychiatry 2008; 21:290–295

    Article  PubMed  Google Scholar 

  138. Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci 2007; 10:1110–1115

    Article  PubMed  CAS  Google Scholar 

  139. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59:1116–1127

    Article  PubMed  CAS  Google Scholar 

  140. Sullivan GM, Hatterer JA, Herbert J, et al. Low levels of transthyretin in the CSF of depressed patients. Am J Psychiatry 1999; 156:710–715

    PubMed  CAS  Google Scholar 

  141. Sullivan GM, Mann JJ, Oquendo MA, et al. Low cerebrospinal fluid transthyretin levels in depression: correlations with suicidal ideation and low serotonin function. Biol Psychiatry 2006; 60:500–506

    Article  PubMed  CAS  Google Scholar 

  142. Sousa JC, Grandela C, Fernandez-Ruiz J, et al. Transthyretin is involved in depression-like behaviour and exploratory activity. J Neurochem 2004; 88:1052–1058

    Article  PubMed  CAS  Google Scholar 

  143. Sousa JC, de Escobar GM, Oliveira P, et al. Transthyretin is not necessary for thyroid ihormone metabolism in conditions of increased hormone demand. J Endocrinol 2005; 187:257–266

    Article  PubMed  CAS  Google Scholar 

  144. Bailey SJ, McCaffery PJ. Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. In: Ritsner MS (ed) The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes. Springer; 2009, pp. 171–190

    Google Scholar 

  145. DeBattista C. Augmentation and combination strategies for depression. J Psychopharmacol 2006; 20:11–18

    Article  PubMed  CAS  Google Scholar 

  146. Altshuler LL, Bauer M, Frye MA, et al. Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature. Am J Psychiatry 2001; 158:1617–1622

    Article  PubMed  CAS  Google Scholar 

  147. Aronson R, Offman HJ, Joffe RT, et al. Triiodothyronine augmentation in the treatment of refractory depression. A meta-analysis. Arch Gen Psychiatry 1996; 53:842–848

    Article  PubMed  CAS  Google Scholar 

  148. Gitlin MJ, Weiner H, Fairbanks L, et al. Failure of T3 to potentiate tricyclic antidepressant response. J Affect Disord 1987; 13:267–272

    Article  PubMed  CAS  Google Scholar 

  149. Cooper-Kazaz R, Apter JT, Cohen R, et al. Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry 2007; 64:679–688

    Article  PubMed  CAS  Google Scholar 

  150. Thase ME. Therapeutic alternatives for difficult-to-treat depression: a narrative review of the state of the evidence. CNS Spectr 2004; 9:808–816, 18–21

    PubMed  Google Scholar 

  151. Joffe RT, Singer W. A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants. Psychiatry Res 1990; 32:241–251

    Article  PubMed  CAS  Google Scholar 

  152. Bunevicius R, Kazanavicius G, Zalinkevicius R, et al. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999; 340:424–429

    Article  PubMed  CAS  Google Scholar 

  153. Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2007; 26:551–554

    Article  PubMed  CAS  Google Scholar 

  154. Jorde R, Waterloo K, Saleh F, et al. Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromso study. J Neurol 2006; 253:464–470

    Article  PubMed  CAS  Google Scholar 

  155. Wilkins CH, Sheline YI, Roe CM, et al. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006; 14: 1032–1040

    Article  PubMed  Google Scholar 

  156. Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998; 135:319–323

    Article  CAS  Google Scholar 

  157. Vieth R, Kimball S, Hu A, et al. Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J 2004; 3:8

    Article  PubMed  CAS  Google Scholar 

  158. Gloth FM 3rd, Alam W, Hollis B. Vitamin D vs. broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 1999; 3:5–7

    PubMed  Google Scholar 

  159. Partonen T. Vitamin D and serotonin in winter. Med Hypotheses 1998; 51:267–268

    Article  PubMed  CAS  Google Scholar 

  160. Neumeister A, Konstantinidis A, Praschak-Rieder N, et al. Monoaminergic function in the pathogenesis of seasonal affective disorder. Int J Neuropsychopharmacol 2001; 4:409–420

    Article  PubMed  CAS  Google Scholar 

  161. Stumpf WE, Privette TH. Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. Psychopharmacology (Berl) 1989; 97:285–294

    Article  CAS  Google Scholar 

  162. Neumeister A, Praschak-Rieder N, Besselmann B, et al. Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Arch Gen Psychiatry 1997; 54:133–138

    Article  PubMed  CAS  Google Scholar 

  163. Uitterlinden AG, Fang Y, van Meurs JBJ, et al. Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. The Journal of Steroid Biochemistry and Molecular Biology 2004; 89–90:187–193

    Article  PubMed  CAS  Google Scholar 

  164. Kuningas M, Mooijaart SP, Jolles J, et al. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiology of Aging 2009; 30:466–473

    Article  PubMed  CAS  Google Scholar 

  165. Kalueff AV, Lou YR, Laaksi I, et al. Impaired motor performance in mice lacking neurosteroid vitamin D receptors. Brain Res Bull 2004; 64:25–29

    Article  PubMed  CAS  Google Scholar 

  166. Kalueff AV, Keisala T, Minasyan A, et al. Behavioural anomalies in mice evoked by “Tokyo” disruption of the Vitamin D receptor gene. Neurosci Res 2006; 54:254–260

    Article  PubMed  CAS  Google Scholar 

  167. Landfield PW, Cadwallader-Neal L. Long-term treatment with Calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats. Neurobiol Aging 1998; 19:469–477

    Article  PubMed  CAS  Google Scholar 

  168. Susser ES, Lin SP. Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944–1945. Arch Gen Psychiatry 1992; 49:983–988

    Article  PubMed  CAS  Google Scholar 

  169. St Clair D, Xu M, Wang P, et al. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959–1961. JAMA 2005; 294:557–562

    Article  PubMed  CAS  Google Scholar 

  170. Woods BT, Ward KE, Johnson EH. Meta-analysis of the time-course of brain volume reduction in schizophrenia: implications for pathogenesis and early treatment. Schizophr Res 2005; 73:221–228

    Article  PubMed  Google Scholar 

  171. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999; 122(Pt 4):593–624

    Article  PubMed  Google Scholar 

  172. Woodruff PW, McManus IC, David AS. Meta-analysis of corpus callosum size in schizophrenia. J Neurol Neurosurg Psychiatry 1995; 58:457–461

    Article  PubMed  CAS  Google Scholar 

  173. McGrath J, Eyles D, Mowry B, et al. Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophr Res 2003; 63:73–78

    Article  PubMed  Google Scholar 

  174. McGrath J, Saari K, Hakko H, et al. Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophr Res 2004; 67:237–245

    Article  PubMed  Google Scholar 

  175. Schneider B, Weber B, Frensch A, et al. Vitamin D in schizophrenia, major depression and alcoholism. J Neural Transm 2000; 107:839–842

    Article  PubMed  CAS  Google Scholar 

  176. Jackson IM. The thyroid axis and depression. Thyroid 1998; 8:951–956

    Article  PubMed  CAS  Google Scholar 

  177. Alkemade A, Unmehopa UA, Brouwer JP, et al. Decreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression. Mol Psychiatry 2003; 8:838–839

    Article  PubMed  CAS  Google Scholar 

  178. Baloch Z, Carayon P, Conte-Devolx B, et al. Guidelines Committee, National Academy of Clinical Biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003; 13:3–126

    Article  PubMed  Google Scholar 

  179. Escobar-Morreale HF, Botella-Carretero JI, Escobar del Rey F, et al. REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine. J Clin Endocrinol Metab 2005; 90:4946–4954

    Article  PubMed  CAS  Google Scholar 

  180. Prange AJ, Jr., Wilson IC, Rabon AM, et al. Enhancement of imipramine antidepressant activity by thyroid hormone. Am J Psychiatry 1969; 126:457–469

    PubMed  CAS  Google Scholar 

  181. Ayd FJ. Lexicon of Psychiatry, Neurology, and the Neurosciences, 2nd edn, Lippincott Williams and Wilkins; 2000

    Google Scholar 

  182. Bauer M, Berghofer A, Bschor T, et al. Supraphysiological doses of L-thyroxine in the maintenance treatment of prophylaxis-resistant affective disorders. Neuropsychopharmacology 2002; 27:620–628

    PubMed  CAS  Google Scholar 

  183. Bauer M, London ED, Rasgon N, et al. Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry 2005; 10:456–469

    Article  PubMed  CAS  Google Scholar 

  184. Bauer M, Baur H, Berghofer A, et al. Effects of supraphysiological thyroxine administration in healthy controls and patients with depressive disorders. J Affect Disord 2002; 68:285–294

    Article  PubMed  CAS  Google Scholar 

  185. Krausz Y, Freedman N, Lester H, et al. Regional cerebral blood flow in patients with mild hypothyroidism. J Nucl Med 2004; 45:1712–1715

    PubMed  Google Scholar 

  186. Schraml FV, Beason-Held LL, Fletcher DW, et al. Cerebral accumulation of Tc-99m ethyl cysteinate dimer (ECD) in severe, transient hypothyroidism. J Cereb Blood Flow Metab 2006; 26:321–329

    Article  PubMed  CAS  Google Scholar 

  187. Krausz Y, Freedman N, Lester H, et al. Brain SPECT study of common ground between hypothyroidism and depression. Int J Neuropsychopharmacol 2007; 10:99–106

    Article  PubMed  Google Scholar 

  188. Nagamachi S, Jinnouchi S, Nishii R, et al. Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy – analysis by tc-99m-HMPAO and SPM96. Ann Nucl Med 2004; 18:469–477

    Article  PubMed  Google Scholar 

  189. Constant EL, de Volder AG, Ivanoiu A, et al. Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. J Clin Endocrinol Metab 2001; 86:3864–3870

    Article  PubMed  CAS  Google Scholar 

  190. Smith JW, Evans AT, Costall B, et al. Thyroid hormones, brain function and cognition: a brief review. Neurosci Biobehav Rev 2002; 26:45–60

    Article  PubMed  CAS  Google Scholar 

  191. Samuels MH. Cognitive function in untreated hypothyroidism and hyperthyroidism. Curr Opin Endocrinol Diabetes Obes 2008; 15:429–433

    Article  PubMed  Google Scholar 

  192. Zhu DF, Wang ZX, Zhang DR, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain 2006; 129:2923–2930

    Article  PubMed  Google Scholar 

  193. Sui L, Wang F, Li BM. Adult-onset hypothyroidism impairs paired-pulse facilitation and long-term potentiation of the rat dorsal hippocampo-medial prefrontal cortex pathway in vivo. Brain Res 2006; 1096:53–60

    Article  PubMed  CAS  Google Scholar 

  194. Chen SJ, Sweatt JD, Klann E. Enhanced phosphorylation of the postsynaptic protein kinase C substrate RC3/neurogranin during long-term potentiation. Brain Res 1997; 749:181–187

    Article  PubMed  CAS  Google Scholar 

  195. Iniguez MA, Rodriguez-Pena A, Ibarrola N, et al. Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate. Endocrinology 1993; 133: 467–473

    Article  PubMed  CAS  Google Scholar 

  196. Martinez de Arrieta C, Morte B, Coloma A, et al. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. Endocrinology 1999; 140:335–343

    Article  Google Scholar 

  197. Wilcoxon JS, Nadolski GJ, Samarut J, et al. Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Behav Brain Res 2007; 177:109–116

    Article  PubMed  CAS  Google Scholar 

  198. Vallortigara J, Alfos S, Micheau J, et al. T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior. Neurobiol Dis 2008; 31:378–385

    Article  PubMed  CAS  Google Scholar 

  199. Broadbelt K, Ramprasaud A, Jones LB. Evidence of altered neurogranin immunoreactivity in areas 9 and 32 of schizophrenic prefrontal cortex. Schizophr Res 2006; 87:6–14

    Article  PubMed  Google Scholar 

  200. Ruano D, Aulchenko YS, Macedo A, et al. Association of the gene encoding neurogranin with schizophrenia in males. J Psychiatr Res 2008; 42:125–133

    Article  PubMed  Google Scholar 

  201. Lakhan SE, Vieira KF. Nutritional therapies for mental disorders. Nutr J 2008; 7:2

    Article  PubMed  CAS  Google Scholar 

  202. Ross BM, Seguin J, Sieswerda LE. Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid? Lipids Health Dis 2007; 6:21

    Article  PubMed  CAS  Google Scholar 

  203. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008; 22:982–1001

    Article  PubMed  CAS  Google Scholar 

  204. Kesby JP, Burne TH, McGrath JJ, et al. Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia. Biol Psychiatry 2006; 60:591–596

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

We would like to thank Dr. Michelle Lane for her reading of the text and excellent suggestions as well as thanking Jemma Ransom for her reading of the section on schizophrenia.

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  1. Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath, Avon, UK

    Sarah J. Bailey (Lecturer)

  2. Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK

    Peter J. McCaffery

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Correspondence to Peter J. McCaffery .

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    Michael S. Ritsner

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Bailey, S.J., McCaffery, P.J. (2010). Vulnerability of the Brain to Neuropsychiatric Disorders Resulting from Abnormal Thyroid Hormone or Vitamin D Homeostasis. In: Ritsner, M. (eds) Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8553-5_5

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