Abstract
In the last years a large number of infectious agents including virus, bacteria and parasites have been identified as direct causes or as risk factors to specific cancers around the world. Among the parasites linked to oncogenesis in humans there are strong associations. Particularly, Schistosoma haematobium is usually recognized as a cause of urinary bladder carcinoma. Some hepatic and colorectal cancers have been linked to infection by S. japonicum or S. mansoni. Moreover, a high proportion of cholangiocarcinoma in Far-East countries was imputable to Opisthorchiidae liver flukes. Among the parasitic Protists, the Apicomplexan Theileria annulata and T. parva, which are the agents of theileriosis in cows, induce often lethal lymphoproliferative process in these animals. The association between Cryptosporidium and digestive carcinomas has also been reported in a clinic study in Poland. More recently, the ability of C. parvum to induce neoplastic changes was established experimentally. This model revealed that C. parvum strains are able to induce gastrointestinal intraepithelial neoplasia in dexamethasone-treated SCID mice. Neoplastic lesions spread often to more than one digestive organ, and severity correlated with the inoculum size and the duration of the infection. Further studies are needed in order to characterize this process in mice, and to explore its occurrence in human cryptosporidiosis.
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References
Bhagwandeen SB (1976) Schistosomiasis and carcinoma of the bladder in Zambia. S Afr Med J 50:1616–1620
Caccio SM, Pozio E (2006) Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis. Expert Rev Anti Infect Ther 4:429–443
Certad G, Ngouanesavanh T, Guyot K, Gantois N, Chassat T, Mouray A, Fleurisse L, Pinon A, Cailliez JC, Dei-Cas E, Creusy C (2007) Cryptosporidium parvum, a potential cause of colic adenocarcinoma. Infect Agent Cancer 2:22
Certad G, Creusy C, Ngouanesavanh T, Guyot K, Gantois N, Mouray A, Chassat T, Flament N, Fleurisse L, Pinon A, Delhaes L, Dei-Cas E (2010) Development of Cryptosporidium parvum induced gastro-intestinal neoplasia in SCID mice: Severity of lesions is correlated with infection intensity. Am J Trop Med Hyg 82:257–265
Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, LaRusso NF (2001) Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis. Gastroenterology 120:1774–1783
Darwish MA, Raouf TA, Rushdy P, Constantine NT, Rao MR, Edelman R (1993) Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors. Am J Trop Med Hyg 49:440–447
de Martel C, Franceschi S (2009) Infections and cancer: Established associations and new hypotheses. Crit Rev Oncol Hematol 70:183–194
Dobbelaere DA, Fernandez PC, Heussler VT (2000) Theileria parva: taking control of host cell proliferation and survival mechanisms. Cell Microbiol 2:91–99
Dobbelaere DA, Rottenberg S (2003) Theileria-induced leukocyte transformation. Curr Opin Microbiol 6:377–382
Halim AB, Garry RF, Dash S, Gerber MA (1999) Effect of schistosomiasis and hepatitis on liver disease. Am J Trop Med Hyg 60:915–920
Heine J, Moon HW, Woodmansee DB (1984) Persistent Cryptosporidium infection in congenitally athymic (nude) mice. Infect Immun 43:856–859
Heussler VT, Kuenzi P, Rottenberg S (2001) Inhibition of apoptosis by intracellular protozoan parasites. Int J Parasitol 31:1166–1176
Hicks RM, Ismail MM, Walters CL, Beecham PT, Rabie MF, El Alamy MA (1982) Association of bacteriuria and urinary nitrosamine formation with Schistosoma haematobium infection in the Qalyub area of Egypt. Trans R Soc Trop Med Hyg 76:519–527
Izquierdo J, Antunez I, Calderon MT, Perez Giraldo C, Munoz Sanz A (1988) Diarrhea caused by Cryptosporidium and colonic neoplasia. Rev Clin Esp 182:393–394
Khurana S, Dubey ML, Malla N (2005) Association of parasitic infections and cancers. Indian J Med Microbiol 23:74–79
Laha T, Pinlaor P, Mulvenna J, Sripa B, Sripa M, Smout MJ, Gasser RB, Brindley PJ, Loukas A (2007) Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini. BMC Genomics 8:189
Lizundia R, Chaussepied M, Huerre M, Werling D, Di Santo JP, Langsley G (2006) c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria. Cancer Res 66:6105–6110
Lopez-Velez R, Tarazona R, Garcia Camacho A, Gomez-Mampaso E, Guerrero A, Moreira V, Villanueva R (1995) Intestinal and extraintestinal cryptosporidiosis in AIDS patients. Eur J Clin Microbiol Infect Dis 14:677–681
Lowe SW, Lin AW (2000) Apoptosis in cancer. Carcinogenesis 21:485–495
Mele R, Gomez Morales MA, Tosini F, Pozio E (2004) Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infect Immun 72:6061–6067
Pagano J, Blaser M, Buendia M, Damania B, Khalili K, Raab-Traub N, Roizman B (2004) Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 14:453–471
Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118:3030–3044
Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, Holmberg SD, Brooks JT (2008) Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann Intern Med 148:728–736
Pozio E, Morales MA (2005) The impact of HIV-protease inhibitors on opportunistic parasites. Trends Parasitol 21:58–63
Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ (2007) Liver fluke induces cholangiocarcinoma. PLoS Med 4:e201
Sulzyc-Bielicka V, Kuzna-Grygiel W, Kolodziejczyk L, Bielicki D, Kladny J, Stepien-Korzonek M, Telatynska-Smieszek B (2007) Cryptosporidiosis in patients with colorectal cancer. J Parasitol 93:722–724
Sunnotel O, Lowery CJ, Moore JE, Dooley JS, Xiao L, Millar BC, Rooney PJ, Snelling WJ (2006) Cryptosporidium. Lett Appl Microbiol 43:7–16
Uhl EW, Jacobson E, Bartick TE, Micinilio J, Schimdt R (2001) Aural-pharyngeal polyps associated with Cryptosporidium infection in three iguanas (Iguana iguana). Vet Pathol 38:239–242
Xiao L, Fayer R, Ryan U, Upton SJ (2004) Cryptosporidium taxonomy: recent advances and implications for public health. Clin Microbiol Rev 17:72–97
Ziegler J, Buonaguro F (2009) Infectious agents and human malignancies. Front Biosci 1:3455–3464
zur Hausen H (2009) The search for infectious causes of human cancers: where and why. Virology 392:1–10
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Creusy, C., Certad, G., Guyot, K., Dei-Cas, E. (2010). Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum . In: Viola Magni, M. (eds) Detection of Bacteria, Viruses, Parasites and Fungi. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8544-3_16
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