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Life Extension by Tissue and Organ Replacement

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The Future of Aging

Abstract

A major feature of aging is a mounting incidence of organ failure. Heart failure is the major cause of death, and organ failure in general accounts for a large percentage of all age-related deaths. The ability to grow replacement organs in vitro or in vivo and to transplant them as needed would, by itself, address a great deal of the present morbidity and mortality associated with aging. In this chapter, we review present day successes in creating viable human organs that are functioning today in patients who need them as well as research that is leading to even greater capabilities for organ and tissue replacement in the future.

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Acknowledgment

The author wishes to thank Jennifer L. Olson, Ph.D. for editorial assistance with this manuscript.

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Authors and Affiliations

  1. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA

    Anthony Atala

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  1. Anthony Atala
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Correspondence to Anthony Atala .

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  1. Intervene Biomedical, LLC, Box 478, Norco, CA, 92860, USA

    Gregory M. Fahy

  2. BioTime, Inc., 1301 Harbor Bay Parkway, Alameda, CA, 94502, USA

    Michael D. West

  3. Institute of Molecular Biology Department of Chemistry and Biochemistry Young Hall, University of California, Los Angeles, CA, 90095-1569, USA

    L. Stephen Coles

  4. Critical Care Research, Inc., 10743 Civic Center Drive, Rancho Cucamonga, CA, 91730, USA

    Steven B. Harris

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Atala, A. (2010). Life Extension by Tissue and Organ Replacement. In: Fahy, G.M., West, M.D., Coles, L.S., Harris, S.B. (eds) The Future of Aging. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3999-6_17

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