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The Use of Phthalocyanines and Related Complexes in Photodynamic Therapy

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Photosensitizers in Medicine, Environment, and Security

Abstract

The phthalocyanines and porphyrins are the most used compounds, called photosensitizers (PS) into photodynamic therapy, due to their NIR absorbing wavelenghts, non-toxicity and high photochemical efficiency. The aim of this chapter is to achieve a better understanding of the phthalocyanines and related compounds, like free bases and metallo-complexes and their sensitizer properties, especially. The photophysical properties (absorption, triplet state, singlet oxygen, photobleaching, and fluorescence quantum yields, and triplet lifetimes so on) are discussed well correlated with their photodynamic activity. Their photodynamic tests in vitro on different cells lines, is discussed properly, taking into account the huge number of existing publications. Some clinical results obtained by using phthalocyanines, porphyrins and related compounds are discussed, too, in order to provide initial data on how currently used PS differ regarding basic PDT-related properties.

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Authors and Affiliations

  1. Analytical Department, National Institute of R&D for Chemistry and Petrochemistry – ICECHIM, 202 Splaiul Independentei, Bucharest, 060021, Romania

    Rodica-Mariana Ion

  2. Faculty of Materials Engineering, Mecathronics and Robotics, Valahia University, 013200, Targoviste, Romania

    Rodica-Mariana Ion

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  1. Dept. Chemistry, Rhodes University, Grahamstown, 6140, South Africa

    Tebello Nyokong

  2. Dept. Chemistry, Gebze Institute of Technology, Gebze, Kocaeli, Turkey

    Vefa Ahsen

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Ion, RM. (2011). The Use of Phthalocyanines and Related Complexes in Photodynamic Therapy. In: Nyokong, T., Ahsen, V. (eds) Photosensitizers in Medicine, Environment, and Security. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3872-2_6

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