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Bifunctional Acid-Base Catalysis

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Enantioselective Organocatalyzed Reactions I

Abstract

Acid-base catalysis with bifunctional catalysts is a very prominent catalytic strategy in both small-molecule organocatalysts as well as enzyme catalysis. In both worlds, small-molecule catalysts and enzymatic catalysis, a variety of different general acids or hydrogen bond donors are used. In this chapter, important parallels between small molecule catalysts and enzymes are discussed, and a comparison is also made to the emerging field of frustrated Lewis pair catalysis.

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Authors and Affiliations

  1. Department of Chemistry, University of Jyväskylä, 35, FI-40014, Jyväskylä, Finland

    Petri M. Pihko & Hasibur Rahaman

Authors
  1. Petri M. Pihko
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  2. Hasibur Rahaman
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Correspondence to Petri M. Pihko .

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Editors and Affiliations

  1. Department of Chemistry, Humboldt University Berlin, Brook-Taylor-Str. 2, Berlin, 12489, Berlin, Germany

    Rainer Mahrwald

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Pihko, P.M., Rahaman, H. (2011). Bifunctional Acid-Base Catalysis. In: Mahrwald, R. (eds) Enantioselective Organocatalyzed Reactions I. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3865-4_6

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