Abstract
The material properties of biological materials, often derived from experiments, are found to vary by orders of magnitude. This disparity in experimentally-derived mechanical properties can be understood only by mathematical models that correlate the structural constituents to its mechanical response. New mechano-biological computational models that consider the effect of microstructural constituents on the response of biological materials are considered in this paper. Various mathematical models are presented to study the macroscopic effects, such as deformation and diffusion in tissues, using multi-scale computational models. The implementation of the computational models for the determination of mechanical behaviour in pathological conditions like cancer progression, cardiovascular diseases, and gynaecological conditions are discussed. The significance of this work lies in the use of a multi-physical modelling of the complex material geometry as well as physical processes representing physiological systems, thereby establishing a suitable and efficient multi-scale computational framework.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mow VC, Holmes MH, Lai WM (1984) Fluid transport and mechanical properties of articular cartilage: A review. Journal of Biomechanics 17: 377–394
Spilker RL, A MT (1990) A mixed-penalty finite element formulation of the linear biphasic theory for soft tissues. International Journal for Numerical Methods In Engineering 30: 1063–1082
Hou JS, Holmes MH, Lai WM, Mow VC (1989) Boundary conditions at the cartilage-synovial fluid interface for joint lubrication and theoretical verifications. Journal of Biomechanical Engineering 111: 78–87
Tang D, Yang J, Yang C, Ku DN (1999) A nonlinear axisymmetric model with fluid-wall interactions for steady viscous flow in stenotic elastic tubes. Journal of Biomechanical Engineering 121: 494–501
Theodorou G, Bellet D (1986) Laminar flows of a non-Newtonian fluid in mild stenosis. Computer Methods in Applied Mechanics and Engineering 54: 111–123
Sciarretta J, Samani A, Bishop J, Plewes DB (2002) MR validation of soft tissue mimicing phanton deformation as modeled by nonlinear finite element analysis. Med Phys 29: 65–72
Plewes DB, Bishop J, Samani A, J S (2000) Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography. Physics in Medicine and Biology 45: 1591–1610
Newcomb P, Weiss S, Storer B, Scholes D, Young B (1991) Breast self examination in relation to the occurrence of advanced breast cancer. J Natl Cancer Inst 83: 260–265
Kuszyk BS, Corl FM, Franano NF, Bluemke DA, Hofmann LV, Fortman BJ, Fishman EK (2001) Tumor transport physiology: Implications for imaging and imaging-guided therapy. American Journal of Roentgeology 177: 747–753
Buhimschi CS, Buhimschi IA, Yu C, Wang H, Sharer DJ, Diamond MP, Petkova AP, Garfield RE, Saade GR, Weiner CP (2006) The effect of dystocia and previous cesarean uterine scar on the tensile properties of the lower uterine segment. American Journal of Obstetrics and Gynecology 194: 873–883
Buhimschi CS, Buhimschi IA, Patel S, Malinow AM, Weiner CP (2005) Rupture of the uterine scar during term labour: contractility or biochemistry? BJOG: An International Journal of Obstetrics and Gynaecology 112: 38–42 DOI:10.1111/j.1471-0528.2004.00300.x
Acknowledgments
The research reported herein was supported by the Oscar S. Wyatt Endowed Chair account at Texas A&M University, College Station.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media B.V.
About this paper
Cite this paper
Unnikrishnan, V.U., Unnikrishnan, G.U., Reddy, J.N. (2010). Multiscale Computational Analysis of Biomechanical Systems. In: Dattaguru, B., Gopalakrishnan, S., Aatre, V. (eds) IUTAM Symposium on Multi-Functional Material Structures and Systems. IUTAM Bookseries (closed), vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3771-8_13
Download citation
DOI: https://doi.org/10.1007/978-90-481-3771-8_13
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-3770-1
Online ISBN: 978-90-481-3771-8
eBook Packages: EngineeringEngineering (R0)