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Chemical Carcinogenesis Role of Chloroform – Further Studies

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Mechanisms of Oncogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 12))

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Abstract

Since the previous version of this chapter [1], there have been numerous studies on chloroform (CHC~:J (CAS No. 67-66-3)) in order to explain the mechanism of its action. CHCl3 had detrimental or beneficial effects in various animal studies, depending on the solvent, the species, and the sex of the animals, in addition to other factors. The presence of very small levels of CHCl3 in chlorine-treated water remains a matter for much discussion among environmental groups, the US EPA and the community of toxicologists [2]. The International Agency for Research on Cancer (IARC) considers that there is inadequate evidence for the carcinogenicity of chlorinated drinking water in either animals or humans [3]. A report that weathering of organic matter leads to accumulation of halogenated organic compounds indicates that such occurrences should be considered in risk assessment [4]

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  1. Formerly with Division of Cancer Etiology, National Cancer Institute, Rockville, MD, 20850, USA

    Elizabeth K. Weisburger

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  1. Research Institute, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, USA

    Domenico Coppola

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Weisburger, E.K. (2010). Chemical Carcinogenesis Role of Chloroform – Further Studies. In: Coppola, D. (eds) Mechanisms of Oncogenesis. Cancer Growth and Progression, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3725-1_4

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