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Molecular Mechanisms of Central Nervous System Metastasis

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Mechanisms of Oncogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 12))

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Abstract

Brain metastasis occurs in a significant number of patients with systemic malignancies and despite a wide range of therapeutic interventions, morbidity and mortality remain high. The mechanisms that impact metastases to the CNS remain unclear. The migratory and invasive properties of the individual primary tumor are directly related to its metastatic potential and malignant cells must manifest these properties in order to attain a more aggressive, and therefore more invasive phenotype. The acquisition of such properties permits migration and invasion through the basement membrane and interaction with the extracellular matrix. Although invasion into the lymphatics and/or vasculature followed by eventual extravasation is the primary physical modality that facilitates metastases from the primary site to distant anatomic sites, it is at the molecular level that expression of critical proteins is altered, effecting pathways within the cell that allow enhanced migration and invasion Many of the molecules and pathways are involved in several different steps of metastasis and often influence multiple pathophysiologic components such as growth, proliferation, angiogenesis, apoptosis and migration. Many of these actions occur concurrently, and frequently are interdependent. This chapter presents a brief overview of some of the molecular mechanisms implicated in the metastatic process.

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Authors and Affiliations

  1. Department of Anatomic Pathology and Neuro-Oncology Program, Moffitt Cancer Center University of South Florida, Tampa, FL, USA

    Amyn M. Rojiani

  2. Departments of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA

    Mumtaz V Rojiani

  3. Department of Neuro-Oncology, Moffitt Cancer Center, Tampa, FL, USA

    Steven Brem

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  1. Nicole D. Riddle
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  2. Mumtaz V Rojiani
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  4. Amyn M. Rojiani
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Correspondence to Amyn M. Rojiani .

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  1. Research Institute, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, USA

    Domenico Coppola

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Riddle, N.D., Rojiani, M.V., Brem, S., Rojiani, A.M. (2010). Molecular Mechanisms of Central Nervous System Metastasis. In: Coppola, D. (eds) Mechanisms of Oncogenesis. Cancer Growth and Progression, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3725-1_11

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