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Comparative Bioaffinity Studies for In-Vitro Cell Assays on MEMS-Based Devices

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Sensors and Microsystems

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 54))

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Abstract

Nowadays, bioaffinity studies of materials are playing a key role in the realization of microdevices for a wide number of biological applications in cell-based assays such as drug screening, cell tracking and transfection. The aim of this research is to evaluate the bioaffinity of different substrates often employed in microfabrication techniques, in order to check the optimal materials aimed at enhancing cell growth or improving cell confinement. Bioaffinity has been tested in the presence of nanostructured TiO2 films produced by Pulsed Microplasma Cluster Source (PMCS). To explore the difference in affinity among these materials, SKOV-3 cells have been cultivated over them by performing studies in terms of morphological appearance and cell density. Both of these aspects have been assessed with fluorescence microscopy and also the surface chemistry has been investigated by means of X-ray Photoelectron Spectroscopy (XPS).

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Reference

  1. D. M. Brunette, P. Tengvall, M. Textor, P. Thomsen (editors), “Titanium in medicine: material science, surface science, engineering, biological responses and medical applications”. Berlin: Springer, 2001.

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Author information

Authors and Affiliations

  1. FBK, Materials and Microsystems Center – BIOMEMS Unit, Via Sommarive 18, 38123, Povo, Tn, Italy

    C. Ress, L. Odorizzi, C. Collini & L. Lorenzelli

  2. FBK, Materials and Microsystems Center – M2B2 Unit, Via Sommarive 18, 38123, Povo, Tn, Italy

    S. Forti, C. Pederzolli, L. Lunelli & L. Vanzetti

  3. IFN-CNR, Institute of Photonics and Nanotechnology, Via Alla Cascata 56/C, 38123, Povo, Tn, Italy

    N. Coppedè, T. Toccoli, G. Tarabella & S. Iannotta

Authors
  1. C. Ress
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  2. L. Odorizzi
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  3. C. Collini
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  4. L. Lorenzelli
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  5. S. Forti
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  6. C. Pederzolli
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  7. L. Lunelli
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  8. L. Vanzetti
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  9. N. Coppedè
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  10. T. Toccoli
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  11. G. Tarabella
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  12. S. Iannotta
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Editor information

Editors and Affiliations

  1. Dipto. Ingegneria Elettrica, Università di Pavia, Via Ferrata 1, Pavia, 27100, Italy

    Piero Malcovati

  2. Dipto. Fisica, Università Milano-Bicocca, Piazza della Scienza 3, Milano, 20126, Italy

    Andrea Baschirotto

  3. Dipto. Ingegneria Elettronica, Università di Roma, Tor Vergata, Via del Politecnico 1, Roma, 00133, Italy

    Arnaldo d'Amico

  4. Dipto. Ingegneria Eletronica, Universita di Roma - Tor Vergata, Via Orazio Raimondo, Roma, 00173, Italy

    Corrado Natale

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© 2010 Springer Science+Business Media B.V.

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Ress, C. et al. (2010). Comparative Bioaffinity Studies for In-Vitro Cell Assays on MEMS-Based Devices. In: Malcovati, P., Baschirotto, A., d'Amico, A., Natale, C. (eds) Sensors and Microsystems. Lecture Notes in Electrical Engineering, vol 54. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3606-3_13

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  • DOI: https://doi.org/10.1007/978-90-481-3606-3_13

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-3605-6

  • Online ISBN: 978-90-481-3606-3

  • eBook Packages: EngineeringEngineering (R0)

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