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Bacterial Chromatin pp 149–173Cite as

Nucleoid-Associated Proteins: Structural Properties

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Abstract

This chapter summarizes the structural details and functional properties of a representative selection of nucleoid-associated proteins (NAPs), consisting of FIS, H-NS, LRP, IHF, HU and Dps. Currently, high resolution structural information of the complete proteins is available for FIS, LRP, IHF, HU and Dps, while for H-NS structures have only been solved for the separate C- and N-terminal halves of the protein. In some cases, such as IHF or HU, structures of the proteins in complex with their target DNA have been determined. For the other proteins reasonable models describing the architecture of the respective protein-DNA complexes have been derived from biochemical and biophysical studies.

A common denominator for all the nucleoid-associated proteins is their property to induce structural deformations to the bound DNA. Each protein appears to affect DNA conformation or topology in a very specific way, however. Despite their general function in compacting DNA these differential properties are key to the high versatility of the NAPs as general and gene-specific regulators in the cell.

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Authors and Affiliations

  1. Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, D-40225, Düsseldorf, Germany

    Ümit Pul & Rolf Wagner

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  1. Ümit Pul
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  2. Rolf Wagner
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Correspondence to Rolf Wagner .

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Editors and Affiliations

  1. Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands

    Remus T. Dame (Faculty of Mathematics and Natural Sciences) (Faculty of Mathematics and Natural Sciences)

  2. Division of Physics and Astronomy Section Physics of Complex Systems, VU University Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands

    Remus T. Dame (Faculty of Mathematics and Natural Sciences) (Faculty of Mathematics and Natural Sciences)

  3. Department of Microbiology School of Genetics and Microbiology, University of Dublin Trinity College, Dublin 2, Ireland

    Charles J. Dorman

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Pul, Ü., Wagner, R. (2010). Nucleoid-Associated Proteins: Structural Properties. In: Dame, R.T., Dorman, C.J. (eds) Bacterial Chromatin. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3473-1_8

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