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The Comparative Biology of Aging pp 287–317Cite as

Comparative Skeletal Muscle Aging

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Abstract

The decline in skeletal muscle function is characteristic of aging organisms across species ranging from C. elegans to humans. This is a multifaceted process involving changes in both the quantity (sarcopenia) and quality of skeletal muscle with age. This chapter describes age-related changes in several aspects of muscle function, including energy metabolism, muscle contraction, stem cell and injury repair and response to cellular stress. We pay particular attention to the effect of aging on different muscle fiber types. These fiber type differences, which are often overlooked, may explain some of the apparent contradictory results in the literature.

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Acknowledgements

The authors would like to thank Kevin Conley and Martin Kushmerick for discussions related to skeletal muscle aging. The authors are supported NIH grants AG028455, AG022385, AG032873, AG029052 and the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and an Ellison Medical Foundation New Scholar Award in Aging.

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  1. Department of Radiology, University of Washington, Seattle, WA, 98195, USA

    David J. Marcinek & Jason J. Villarin

  2. Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, 98195, USA

    Jonathan Wanagat

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    Norman S. Wolf

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Marcinek, D.J., Wanagat, J., Villarin, J.J. (2010). Comparative Skeletal Muscle Aging. In: Wolf, N. (eds) The Comparative Biology of Aging. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3465-6_13

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