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Physiological and Pathological Role of Apoptosis

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Apoptosome

Abstract

Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated. The current chapter, besides providing an overview of the apoptotic machinery, will focus on knockout and knockin studies of key components of the apoptosis cascade, and analyses of the apoptosis dysregulation in many pathological conditions such as neurodegeneration, cancer, heart attack, autoimmune disease and virus infections.

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  1. Dulbecco Telethon Institute at the Department of Biology, University of Rome ‘Tor Vergata’, 00133, Rome, Italy

    Virve Cavallucci & Marcello D’Amelio

  2. Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy

    Virve Cavallucci & Marcello D’Amelio

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  1. Dipto. Biologia, Università di Roma, Tor Vergata, Via della Ricerca Scientifica, Roma, 00133, Italy

    Francesco Cecconi

  2. IRCCS, Fondazione Santa Lucia, Via Fosso di Fiorano, Roma, 00143, Italy

    Marcello D'Amelio

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Cavallucci, V., D’Amelio, M. (2010). Physiological and Pathological Role of Apoptosis. In: Cecconi, F., D'Amelio, M. (eds) Apoptosome. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3415-1_1

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