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Heat Shock Protein (HSP)-Based Immunotherapies

  • Hongying Zheng
  • Alexzander AseaEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 5)

Abstract:

Heat Shock Proteins (HSP) are a diverse group of proteins that as molecular chaperons bind to a variety of cell proteins in all cells. HSP also play a significant role in helping the immune system recognize diseased cells. During the past three decades, HSP are found to be a potent agent for tumor immunotherapy and studies towards anti-tumor vaccine development still continue today. HSP-based immunotherapies, which could augment antigen-specific immune responses, are the promising approaches for effective treatment and enduring cure. However, more studies on the role of HSP to induce innate and adaptive immune responses have resulted in new understanding of HSP in immunotherapy. Certain HSP are over expressed in tumor cells and aid tumor cells metastasis. Under this circumstance, HSP were chosen as targets for cancer treatments. Recent evidence further demonstrated that HSP possess immunoregulatory attributes. The high evolutionary conservancy of HSP and their overexpression during inflammation make them as important pathogen-related antigens as well as self antigens. Certain HSP (specifically Hsp60, Hsp65, Hsp70 and Hsp10) have been identified to be involved in the regulation of some autoimmune diseases. Now HSP becomes a double-sided sword. Therefore, HSP are also a tool for manipulating autoimmune inflammation and HSP for immunotherapy of autoimmune diseases are under discovery

Keywords:

Cancer chimeras DNA vaccines fusion proteins heat shock proteins immunotherapy 

Abbreviations

AIA

adjuvant induced arthritis

APC

antigen presenting cells

BCG

Bacillus Calmette-Guérin

CTL

cytotoxic T lymphocytes

DC

dendritic cells

ERK

extracellular-signal regulated kinase

Grp

glucose regulated proteins

HER

human endothelial growth factor receptor

HLA

human leukocyte antigen system

HPV

human papilloma virus

HSF

heat shock factor

Hsp

heat shock proteins

hsp

heat shock protein gene

HSP

heat shock protein family

HSP

heat shock protein family gene

ICD

intracellular domain

IDDM

insulin-dependent diabetes mellitus

IFA

incomplete Freund’s adjuvant

IL

interleukin

NHL

non-Hodgkin lymphoma

NO

nitric oxide

NOD

non-obese diabetic

RA

rheumatoid arthritis

RCC

renal cell carcinoma

RRP

recurrent respiratory papillomatosis

TAA

tumor-associated antigens

TGF-β

transforming growth factor-beta

TNF-α

tumor necrosis factor-alpha

Notes

Acknowledgements

This work was supported in part by a grant from the National Institutes of Health grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M University System Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A. A.).

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Authors and Affiliations

  1. 1.Division of Investigative PathologyThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA
  2. 2.Division of Investigative PathologyThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA

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