Heat Shock Proteins in Vascular Disease

  • Tapan A. MehtaEmail author
Part of the Heat Shock Proteins book series (HESP, volume 5)


There is growing evidence that heat shock proteins (HSP), a family of stress-inducible proteins may be involved in the pathogenesis of atherosclerotic vascular diseases. Here we systematically review the evidence behind this notion. A detailed literature search and extensive bibliographic review of literature relating to HSP and atherosclerotic vascular disease. Atherosclerotic vascular disease is classified into four main areas of presentation: carotid, coronary, aortic and peripheral vascular disease, for consideration in this review. In each of these vascular diseases, the evidence linking HSP and atherosclerosis is outlined in a systematic manner. Current evidence suggests that components of the immune system may be involved in the pathogenesis of atherosclerosis, with HSP acting as auto-antigens in the immune response. HSP are detected in atherosclerotic lesions and antibodies to HSP are increased in patients with vascular disease; the rise often correlating with the severity of atherosclerosis. The levels of anti-HSP antibodies have been shown to be independent predictors of risk and have prognostic value. There is a strong link between heat shock protein expression and the principal manifestations of atherosclerotic vascular diseases. A better understanding of this involvement could lead to the development of new and improved treatment strategies


HSP atherosclerosis carotid disease coronary disease aortic disease 



coronary artery disease


C. Pneumoniae


diabetes mellitus


heat shock proteins


ischaemia reperfusion injury


low-density lipoprotein


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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Academic Surgical UnitUniversity Of HullHullUK
  2. 2.Vascular Laboratory, Hull Royal InfirmaryHullUK

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