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Heat Shock Proteins and Whole Body Physiology pp 57–83Cite as

Heat Shock Protein and Inflammation

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Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract

Heat Shock Proteins (HSP) are important modulators of both anti-inflammatory and pro-inflammatory responses. In this chapter, we address this apparent paradox by focusing on the effects of the highly heat inducible Hsp70 and its transcription machinery. This transcription machinery may exert important effects on inflammation through pathways, which are independent of heat shock proteins. We then discuss disease states where the balance between the anti-inflammatory and pro-inflammatory effectors is critical to disease outcome

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Abbreviations

AP-1:

activator protein 1

APC:

antigen presenting cells

eHSP:

extracellular HSP

GLN:

glutamine

HMGB1:

high-mobility group box 1 protein

HIV:

human immunodeficiency virus

HSF-1:

heat shock transcription factor 1

HSP:

heat shock protein

HSR:

heat shock response

IBD:

inflammatory bowel diseases

IFN-γ:

interferon-gamma

IKK:

IkappaB kinase

IL-6:

interleukin 6

JNK:

c jun amino terminal kinase

LPS:

lipopolysaccharide

MAPK:

mitogen-activated protein kinases

MODS:

multiple organ dysfunction syndrome

NF-κB:

nuclear factor kappa B

NF-IL6:

nuclear factor-IL6

NK:

natural killer cells

SIRS:

systemic inflammatory response syndrome

TLR:

Toll like receptor

TNF-α:

tumor necrosis factor alpha

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  1. Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA

    Fabiano Amorim & Pope L. Moseley

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  1. Fabiano Amorim
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  2. Pope L. Moseley
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Correspondence to Pope L. Moseley .

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  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Amorim, F., Moseley, P.L. (2010). Heat Shock Protein and Inflammation. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_4

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