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Heat Shock Protein and Inflammation

  • Fabiano Amorim
  • Pope L. MoseleyEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 5)

Abstract

Heat Shock Proteins (HSP) are important modulators of both anti-inflammatory and pro-inflammatory responses. In this chapter, we address this apparent paradox by focusing on the effects of the highly heat inducible Hsp70 and its transcription machinery. This transcription machinery may exert important effects on inflammation through pathways, which are independent of heat shock proteins. We then discuss disease states where the balance between the anti-inflammatory and pro-inflammatory effectors is critical to disease outcome

Keywords

Cytokines HSF-1 HSP inflammatory response syndrome heat stroke inflammation heat injury 

Abbreviations

AP-1

activator protein 1

APC

antigen presenting cells

eHSP

extracellular HSP

GLN

glutamine

HMGB1

high-mobility group box 1 protein

HIV

human immunodeficiency virus

HSF-1

heat shock transcription factor 1

HSP

heat shock protein

HSR

heat shock response

IBD

inflammatory bowel diseases

IFN-γ

interferon-gamma

IKK

IkappaB kinase

IL-6

interleukin 6

JNK

c jun amino terminal kinase

LPS

lipopolysaccharide

MAPK

mitogen-activated protein kinases

MODS

multiple organ dysfunction syndrome

NF-κB

nuclear factor kappa B

NF-IL6

nuclear factor-IL6

NK

natural killer cells

SIRS

systemic inflammatory response syndrome

TLR

Toll like receptor

TNF-α

tumor necrosis factor alpha

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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity of New MexicoAlbuquerqueUSA

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