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Heat Shock Proteins, Exercise, and Aging

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Heat Shock Proteins and Whole Body Physiology

Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract

Age-associated losses in muscle mass and strength and greater susceptibility to muscle injury may be attenuated or reversed by exercise training. Increased heat shock protein (HSP) expression is one adaptation in skeletal muscle to exercise which may subsequently protect muscles against stressors. Eccentric loading, treadmill running, resistance training, and functional overload have been shown to increase Hsp72 and Hsp25 content in muscle. Evidence suggests that the muscles of older individuals can respond to exercise with increased HSP expression; however, the responses may be attenuated compared to younger muscles. A sufficient exercise stimulus may be necessary to induce up-regulation of protective HSP in muscle such that even modest reductions in muscle activity and loading that occur with aging may contribute to reduced basal or stress-induced HSP responses in aged muscle. This could contribute to some of the deleterious changes in muscle function since HSP potentially protect muscles against contractile damage, accelerate recovery from injury and reduce activation of inflammatory pathways such as NF-κB and the caspase cascade. The prospect that exercise may increase expression of HSP in aged muscle could have important implications for increasing muscle strength and function and improving quality of life

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Abbreviations

HSF1:

heat shock factor 1

HSP:

heat shock protein

MHC:

myosin heavy chain

NF-κB:

nuclear factor kappa-light-chain-enhancer of activated B cells

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Authors and Affiliations

  1. Drake University, College of Pharmacy and Health Science, Des Moines, IA, 50311, USA

    Kimberly A. Huey & Jeffrey A. Woods

  2. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA

    Victoria Vieira

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  1. Kimberly A. Huey
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  2. Victoria Vieira
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Correspondence to Kimberly A. Huey .

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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Huey, K.A., Vieira, V., Woods, J.A. (2010). Heat Shock Proteins, Exercise, and Aging. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_22

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