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Role of Heat Shock Proteins in Obesity and Type 2 Diabetes

  • Punit Kaur
  • Michael D. Reis
  • Glen R. Couchman
  • Samuel N. Forjuoh
  • John F. GreeneJr
  • Alexzander AseaEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 5)

Abstract

Heat shock proteins (HSP) play an important role in human health and physiology and are known to function intracellularly as cytoprotection proteins by protecting cells against a wide variety of stressors, and extracellularly as chaperokines by stimulating the synthesis of pro-inflammatory cytokines, chemokines, and upregulates co-stimulatory molecule expression on antigen presenting cells, and enhancing natural killer (NK) cell-mediated migration and general anti-tumor responses. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. The recent findings that antibody titers to several HSP are elevated in dyslipidaemic patients and individuals with established vascular disease, and that patients with Type 2 diabetes have reduced gene expression of Hsp72 which correlates with reduced insulin sensitivity point to an important role for HSP in obesity and Type 2 diabetes. This chapter briefly reviews recent advances in our understanding of the role of Hsp70 in obesity and Type 2 diabetes

Keywords

BMI cancer cardiovascular diseases diabetes obesity weight 

Abbreviations

BMI

body mass index

CDC

center for disease control

CRP

C-reactive protein

CVD

cardiovascular disease

FBG

fasting blood glucose

FFA

free fatty acids

GRP

glucose regulated proteins

HSF

heat shock factor

Hsp

heat shock proteins

hsp

heat shock protein gene

HSP

heat shock protein family

IGF-1

insulin growth factor-1

IL

interleukin

JNK

c-jun N-terminal kinase

MAPK

mitogen activated protein kinases

MCP-1

monocyte chemotactic protein-1

NK

natural killer

TNF-α

tumor necrosis factor-alpha

WHO

World Health Organization

Notes

Acknowledgements

The authors thank the Proteomics Core Facility at Scott & White Hospital and Clinic. This work was supported in part by the National Institutes of Health grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M University System Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A. A).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Punit Kaur
    • 1
  • Michael D. Reis
    • 2
  • Glen R. Couchman
    • 2
  • Samuel N. Forjuoh
    • 2
  • John F. GreeneJr
    • 1
  • Alexzander Asea
    • 1
    • 3
    Email author
  1. 1.Division of Investigative PathologyThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA
  2. 2.Department of Family & Community MedicineThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA
  3. 3.Division of Investigative PathologyThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA

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