Exercise Intensity and Duration Affect Blood-Soluble HSP72

  • Kishiko Ogawa
  • Elvira FehrenbachEmail author
Part of the Heat Shock Proteins book series (HESP, volume 5)


Extracellular Hsp72 (eHsp72) is elevated during and after acute bouts of exercise. Concentrations of eHsp72 in plasma or serum are dependent on the duration and intensity of exercise. Active secretory processes rather than passive release due to cell damage are considered to function in the exercise-induced release of eHsp72. Up-regulation of eHsp72 in the circulation following acute exercise may contribute to improved immune function; eHsp72 increases stress resistance after binding to stress sensitive recipients, signals tissue destruction and danger to inflammatory cells, and aids in immunosurveillance by transporting intracellular peptides to distant immune cells. It is uncertain whether this exercise-mediated mechanism for eHsp72-regulated activation of the immune system helps to prevent immunologic diseases


Exercise acute response immune system blood extracellular heat shock protein 72 



antigen-presenting cells


adenosine triphosphate


chemokine receptors


extracellular Hsp72


heat shock proteins


seventy two kilo-dalton HSP


major histocompatibility complex


peripheral blood mononuclear cells


toll-like receptor


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Research Team for Social Participation and Health PromotionTokyo Metropolitan Institute of GerontologyTokyoJapan
  2. 2.Institute of Clinical and Experimental Transfusion Medicine (IKET)University of TuebingenTuebingenGermany

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