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HSP, Exercise, and Antioxidants

  • Bente Klarlund PedersenEmail author
  • Christian Philip Fischer
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 5)

Abstract:

The heat shock proteins (HSP) are a family of highly conserved proteins with critical roles in maintaining cellular homeostasis and in protecting the cell from chronically and acutely stressful conditions. An increased expression of Hsp72 in skeletal muscle appears to be a part of the normal exercise response as well as training adaptation. Regular exercise offers protection against a number of chronic diseases, including type 2 diabetes and the basal expression of Hsp72 mRNA is suppressed in skeletal muscle of patients with type 2 diabetes. Moreover, mechanistic studies show that muscular Hsp72 protects against obesity-induced peripheral insulin resistance. Physical activity provokes an increased production of reactive oxygen species (ROS) and ROS is an inducer of Hsp72. The mechanisms whereby exercise and ROS regulate muscular Hsp72 expression are discussed. Anti-oxidant treatment with the vitamin E isoform γ-tochoferol is a potent inhibitor of exercise-induced expression of muscular Hsp72. This fact may contribute to explain the findings from large clinical studies that antioxidant supplementation may have detrimental effects on morbidity and mortality

Keywords:

Physical activity muscle cytokines physiology vitamin oxidative stress 

Abbreviations

HSP

heat shock proteins

Hsp72

seventy two kilo-Dalton Hsp

IL-6

interleukin-6

L-NAME

nitro-L-arginine methyl ester

rhIL-6

recombinant human IL-6

RNS

reactive nitrogen species

ROS

reactive oxygen species

Notes

Acknowledgements

The Centre of Inflammation and Metabolism is supported by a grant from the Danish National Research Foundation (DG 02-512-555). In addition, support was obtained from the Danish Medical Research Council, and the Commission of the European Communities (contract no. LSHM-CT-2004-005272 EXGENESIS).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Bente Klarlund Pedersen
    • 1
    Email author
  • Christian Philip Fischer
    • 2
  1. 1.Department of Infectious Diseases and CMRCFaculty of Health Sciences, The Centre of Inflammation and Metabolism, University of CopenhagenCopenhagenDenmark
  2. 2.Department of Infectious Diseases and CMRCFaculty of Health Sciences, The Centre of Inflammation and Metabolism, University of CopenhagenCopenhagenDenmark

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