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HSP, Exercise, and Antioxidants

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Heat Shock Proteins and Whole Body Physiology

Part of the book series: Heat Shock Proteins ((HESP,volume 5))

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Abstract:

The heat shock proteins (HSP) are a family of highly conserved proteins with critical roles in maintaining cellular homeostasis and in protecting the cell from chronically and acutely stressful conditions. An increased expression of Hsp72 in skeletal muscle appears to be a part of the normal exercise response as well as training adaptation. Regular exercise offers protection against a number of chronic diseases, including type 2 diabetes and the basal expression of Hsp72 mRNA is suppressed in skeletal muscle of patients with type 2 diabetes. Moreover, mechanistic studies show that muscular Hsp72 protects against obesity-induced peripheral insulin resistance. Physical activity provokes an increased production of reactive oxygen species (ROS) and ROS is an inducer of Hsp72. The mechanisms whereby exercise and ROS regulate muscular Hsp72 expression are discussed. Anti-oxidant treatment with the vitamin E isoform γ-tochoferol is a potent inhibitor of exercise-induced expression of muscular Hsp72. This fact may contribute to explain the findings from large clinical studies that antioxidant supplementation may have detrimental effects on morbidity and mortality

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Abbreviations

HSP:

heat shock proteins

Hsp72:

seventy two kilo-Dalton Hsp

IL-6:

interleukin-6

L-NAME:

nitro-L-arginine methyl ester

rhIL-6:

recombinant human IL-6

RNS:

reactive nitrogen species

ROS:

reactive oxygen species

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Acknowledgements

The Centre of Inflammation and Metabolism is supported by a grant from the Danish National Research Foundation (DG 02-512-555). In addition, support was obtained from the Danish Medical Research Council, and the Commission of the European Communities (contract no. LSHM-CT-2004-005272 EXGENESIS).

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Authors and Affiliations

  1. Department of Infectious Diseases and CMRC, Faculty of Health Sciences, The Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark

    Bente Klarlund Pedersen

  2. Department of Infectious Diseases and CMRC, Faculty of Health Sciences, The Centre of Inflammation and Metabolism, University of Copenhagen, Copenhagen, Denmark

    Christian Philip Fischer

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  1. Bente Klarlund Pedersen
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Correspondence to Bente Klarlund Pedersen .

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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Pedersen, B.K., Fischer, C.P. (2010). HSP, Exercise, and Antioxidants. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_14

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