The 70kDa Heat Shock Protein Family and Learning

  • Martine Ammassari-TeuleEmail author
  • Giuseppina Mariucci
  • Maria Vittoria Ambrosini
Part of the Heat Shock Proteins book series (HESP, volume 5)


This chapter examines data supporting the view that heat shock proteins members of the 70 kDa family (HSP70) interfere with the plastic mechanisms underlying learning and memory. In the first part, we present evidence that rodents trained in tasks taxing specific forms of learning show increased levels of inducible (Hsp72) or constitutive (Hsc70) HSP in the brain regions mediating these learning systems. In the second part, we describe experiments in which exposure to a heat shock (also referred to as heat shock preconditioning) prevents the disruptive effect of amnestic agents on learning performance and synaptic plasticity, and interferes with the learning performance in different species. In the third part, we review data aimed at disentangling specific from non-specific learning effects of increased expression of HSP70 in the brain. We conclude that the experimental conditions in which HSP70 are expressed and the loci where this expression takes place suggest a role for these proteins in synaptic plasticity, learning, and memory


70 kDa Heat shock protein heat shock heat shock factors learning stress motor activity 



Alzheimer’s disease


field excitatory post synaptic potential


heat shock factor


heat shock proteins


Huntington’s disease


70 kDa heat shock protein family

Hsc70 and Hsp73

constitutive 70 kDa HSP

Hsp70 and Hsp72

inducible 70 kDa HSP


stress inducible Hsp72 gene


long-term memory


long-term potentiation


Parkinson’s disease


short-term memory


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Martine Ammassari-Teule
    • 1
    • 2
    Email author
  • Giuseppina Mariucci
    • 3
  • Maria Vittoria Ambrosini
    • 3
  1. 1.Istituto di NeuroscienzeConsiglio Nazionale delle RicercheRomeItaly
  2. 2.Istituto di NeuroscienzeConsiglio Nazionale delle Ricerche and Santa Lucia FoundationRomeItaly
  3. 3.Dipartimento di Medicina Sperimentale e Scienze BiochimicheUniversity of PerugiaPerugiaItaly

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