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The Comparative Anatomy of Islets

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The Islets of Langerhans

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 654))

Abstract

In the past 20 years, numerous publications on a variety of mammalian and non-mammalian species have appeared in the literature to supplement the excellent comparative work performed in the 70s and 80s by the Falkmer, Epple, and Youson groups. What emerges is that islets are much more complex than once thought and show a lot of similarities in rodents and higher primates. The diversity of lifestyles, metabolic demands, and diets has most likely influenced the great diversity in both structure and cell-type content of islets in lower vertebrate species. In this chapter, I try to provide an overview of the evolution from endocrine cell types in invertebrates to the higher mammals and focus on what has been reported in the literature and some of our own experiences and also include a description of other hormones reported to be found in islets.

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Acknowledgments

I would like to thank Nils Wierup, Carsten Godfredsen, and Yana Kvicerova for providing some of the tissue samples used in Fig. 2.4. I would also like to thank my graduate student Carsten Gustavsen for his excellent work in this area of comparative morphological analysis of different species and finally Jan Nygård Jensen, Ole Madsen, and Carsten Gustavsen for helpful comments on the chapter.

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  1. Hagedorn Research Institute, Department of Beta Cell Regeneration, Niels Steensensvej 6, Gentofte, DK2820, Denmark

    R. Scott Heller

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  1. Dept. Clinical Research & Education, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Heller, R.S. (2010). The Comparative Anatomy of Islets. In: Islam, M. (eds) The Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 654. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3271-3_2

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