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Abstract

Pharmacogenomics explores the contribution of genetics to drug safety and specifically examines the single gene interactions with drugs. It also makes use of genetic tests to distinguish among patients whose genetic characteristics predispose them to respond in certain ways to certain medicines. An understanding of the genetic variables that influence drug response could also help pharmaceutical companies design new, more effective therapies.

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References

  • Bellver Capella, V., 2002, Ethics, politics, and rights in pharmacogenomics. Law Hum Genome Rev 17:31–55.

    PubMed  Google Scholar 

  • Blake, C.A., Sobel, B.E., 2008, Progress in pharmacogenomics and its promise for medicine. Exp Biol Med 233:1482–1483.

    Article  CAS  Google Scholar 

  • Cariou, A., Chiche, J.D., Charpentier, J., Dhainaut, J.F., Mira, J.P., 2002, The era of genomics: impact on sepsis clinical trial design. Crit Care Med 5:341–348.

    Article  Google Scholar 

  • Dan, M., Roden, M.D., Russ, B., et al., 2006, Pharmacogenomics: challenges and Opportunities. Annals of Internal Medicine 145(10):749–757.

    Google Scholar 

  • Eichelbaum, M., Ingelman-Sundberg, M., Evans, W.E., 2006, Pharmacogenomics and individualized drug therapy. Annu Rev Med 57:119–137.

    Article  CAS  PubMed  Google Scholar 

  • Evans, W.E., Relling, M.V., 1999, Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487–491.

    Article  CAS  PubMed  Google Scholar 

  • Gupta, M., Kaur, H., Grover, S., Kukreti, R., 2008, Pharmacogenomics and treatment for dementia induced by Alzheimer’s disease. Pharmacogenomics 9:895–903.

    Article  CAS  PubMed  Google Scholar 

  • Johnson, J.A., 2001, Drug target pharmacogenomics: an overview. Am J Pharmacogenomics 1:271–281.

    Article  CAS  PubMed  Google Scholar 

  • Johnson, J.A., Evans, W.E., 2001, Pharmacogenomics: the inherited basis for inter-individual differences in drug response. Annu Rev Genomics Hum Genet 2:9–39.

    Article  PubMed  Google Scholar 

  • Johnson, J.A., Evans, W.E., 2002, Molecular diagnostics as a predictive tool: genetics of drug efficacy and toxicity. Trends Mol Med 8:300–305.

    Article  CAS  PubMed  Google Scholar 

  • Kirchheiner, J., Roots, I., Goldammer, M., Rosenkranz, B., Brockmöller, J., 2005, Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance. Clin Pharmacokinet 44:1209–1225.

    Article  CAS  PubMed  Google Scholar 

  • Kirchheiner, J., Seeringer, A., 2007, Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes. Biochim Biophys Acta 1770:489–494.

    CAS  PubMed  Google Scholar 

  • Kirchheiner, J., Seeringer, A., Brockmöller, J., 2006, State of the art of pharmacogenetic diagnostics in drug therapy. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:995–1003.

    Article  CAS  PubMed  Google Scholar 

  • Krynetski, E.Y., Evans, W.E., 1998, Pharmacogenetics of cancer therapy: getting personal. Am J Hum Genet 63:11–16.

    Article  CAS  PubMed  Google Scholar 

  • Lazarou, J., Pomeranz, B.H., Corey, P.N., 1998, Incidence of adverse drug reactions in hospitalized patients. JAMA 279:1200–1205.

    Article  CAS  PubMed  Google Scholar 

  • Lee, S.S., 2009, Pharmacogenomics and the challenge of health disparities. Public Health Genomics 2:170–179.

    Article  Google Scholar 

  • López-López, M., Guerrero-Camacho, J.L., Familiar-López, I.M., 2004, Pharmacogenomics: the quest for individualized therapy. Rev Neurol 39:1063–1071.

    PubMed  Google Scholar 

  • Mancinelli, L., Cronin, M., Sadee, W., 2000, Pharmacogenomics: The promise of personalized medicine. AAPS Pharm Sci 2:4.

    Google Scholar 

  • Moldrup, C., 2001, Ethical, social and legal implications of pharmacogenomics: a critical review. Community Genet 4:204–214.

    Article  PubMed  Google Scholar 

  • Phillips, K.A., Veenstra, D.L., Oren, E., Lee, J.K., Sadee, W., 2001, The potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review. JAMA 286:2270–2279.

    Article  CAS  PubMed  Google Scholar 

  • Phillips, K.A., Veenstra, D., Sadee, W., 2000, Implications of the genetic revolution for health services research: Pharmacogenomics and improvements in drug therapy. Health Serv Res 35:128–140.

    CAS  PubMed  Google Scholar 

  • Roden, D.M., Altman, R.B., Benowitz, N.L., Flockhart, D.A., Giacomini, K.M., Johnson, J.A., Krauss, R.M., McLeod, H.L., Ratain, M.J., Relling, M.V., Ring, H.Z., Shuldiner, A.R., Weinshilboum, R.M., Weiss, S.T. Pharmacogenetics Research Network, 2006, Pharmacogenomics: challenges and opportunities. Ann Intern Med 145:749–757.

    PubMed  Google Scholar 

  • Sadee, W., 1999, Pharmacogenomics. Brit Med J 319:1286.

    Google Scholar 

  • Sadee, W., 2002, Pharmacogenomics: The Implementation Phase. AAPS Pharm Sci 4:611–614.

    Article  Google Scholar 

  • Shai, R.M., Reichardt, J.K., Chen, T.C., 2008, Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas. Future Oncol 4:525–534.

    Article  PubMed  Google Scholar 

  • Shi, J., Chen, S., 2002, Pharmacogenomics genomics approaches to optimizing drug therapy. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:156–158.

    CAS  PubMed  Google Scholar 

  • Terra, S.G., Johnson, J.A., 2002, Pharmacogenetics, pharmacogenomics, and cardiovascular therapeutics: the way forward. Am J Cardiovasc Drugs 2:287–296.

    Article  CAS  PubMed  Google Scholar 

  • Tolle, R., 2001, Information technology tools for efficient SNP studies. Am J Pharmacogenomics 1:303–314.

    Article  CAS  PubMed  Google Scholar 

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Debnath, M., Prasad, G.B., Bisen, P.S. (2010). Pharmacogenomics. In: Molecular Diagnostics: Promises and Possibilities. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3261-4_26

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