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Mathematical Modeling of Biosensors pp 139–202Cite as

Multi-Layer Models of Biosensors

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Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 9))

Abstract

There are various reasons for applying a multi-layer approach to the modeling of biosensors. Multi-layer models are usually used in the following cases [35, 119, 235, 236]:

  • The bulk solution is assumed to be slightly-stirred or non-stirred. This assumption leads to two-compartment models [51, 60, 102, 120, 286].

  • The enzyme layer is covered with an inert outer membrane [234]. The membrane stabilizes the enzyme layer and creates a diffusion limitation to the substrate, i.e. lowers the substrate concentration in the enzymatic layer and thereby prolongs the calibration curve of the biosensor [152, 166, 229, 238, 258].

  • The electrode is covered with a selective membrane [236]. Selective membranes are usually impermeable to certain molecules and permeable to a desired substance. This arrangement can notably increase the biosensor selectivity. The selective layer can also protect the metal interface of the electrode [16, 47, 91, 157].

  • In multienzyme systems, enzymes are often immobilized separately in different active layers packed in a sandwich-like multi-layer arrangement [13, 14, 15, 113, 184, 242]. This approach seems to be a rather fast and cheap method to design biosensors for different purposes.

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Authors and Affiliations

  1. Dept. Mathematics & Informatics, Vilnius University, Naugarduko 24, LT-03225, Vilnius, Lithuania

    Romas Baronas & Feliksas Ivanauskas

  2. Dept. Chemistry & Bioengineering, Vilnius Gediminas Technical University, Sauletekio Ave. 11, LT-10223, Vilnius, Lithuania

    Juozas Kulys (Fac. Fundamental Sciences)

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Baronas, R., Ivanauskas, F., Kulys, J. (2010). Multi-Layer Models of Biosensors. In: Mathematical Modeling of Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3243-0_8

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