Abstract
Angiogenesis is an important step in the process of cancer growth and wound healing (Folkman 1971). Cancer is always accompanied by angiogenesis. Angiogenesis is a complex of endothelial cell growth through an interaction of growth factors and their ligands and of sustaining matrices. Several sources of vascular endothelium are thought to participate in angiogenesis: sprouting from the preexisting blood vessel or mobilization from the bone marrow and circulation in the blood stream, and anchoring and colonization at the lesion (Asahara et al. 1999; Gunsilius et al. 2000). Whatever the source of angiogenic cells, endothelial cells express specific molecules and proliferate through an interaction with their ligands. In this chapter, the morphologic features of tumor angiogenesis, general endothelial markers of endothelium, and proliferation specific molecule CD105 are discussed.
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References
Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, and Isner JM (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85:221-228
Behrem S, Zarkovic K, Eskinja N, and Jonjic N (2005) Endoglin is a better marker than CD31 in evaluation of angiogenesis in glioblastoma. Croat Med J 46:417-422
Bottela LM, Sanchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Longo C, Vary CPH, Ramirez JR, Friedman S, and Bernabeu C (2002) Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood 100:4001-4010
Burrows FJ, Derbyshire EJ, Tazzari PL, Amlot P, Gazdar AF, King SW, Letarte M, Vitetta ES, and Thorpe PE (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin Cancer Res 1:1623-1634
Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, and Brown PO (2003) Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci 100:10623-10628
Dales JP, Garcia S, Andrac L, Carpentier S, Ramuz O, Lavaut MN, Allasia C, Bonnier P, and Charpin C (2004) Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome. Int J Oncol 24:1197-1204
Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, and Akhurst RJ (1995) Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121:1845-1854
Ding S, Li C, Lin S, Yang Y, Liu D, Han Y, Zhang Y, Li L, Zhou L, and Kumar S (2006) Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions. Hum Pathol 37:861-866
Duff SE, Li C, Garland JM, and Kumar S (2003) CD105 is important for angiogenesis: evidence and potential applications. FASEB J 17:984-992
Faviana P, Boldrini L, Spisni R, Berti P, Galleri D, Biondi R, Camacci T, Materazzi G, Pingitore R, Miccoli P, and Fontanini G (2002) Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. Oncol Rep 9:617-620
Ferrara N (2002) VEGF and the quest for tumor angiogenesis factors. Nat Rev Cancer 2:795-803
Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186
Fonsatti E, Jekunen AP, Kairemo KJA, Coral S, Snellman M, Nicotra MR, Natali PG, Altomonte M, and Maio M (2000) Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model. Clin Cancer Res 6:2037-2043
Fonsatti E, Altomonte M, Nicotra MR, Natali PG, and Maio M (2003) Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene 22:6557-6563
Fonsatti E, and Maio M (2004) Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer. J Transl Med 2:18
Fox SB, Harris AL (2004) Histological quantitation of tumour angiogenesis. APMIS 112:413-430
Graulich W, Nettelbeck DM, Fischer D, Kissel T, and Muller R (1999) Cell type specificity of the human endoglin promoter. Gene 227:55-62
Gunsilius E, Duba HC, Petzer AL, Kahler CM, Grunewald K, Stockhammer G, Gabl C, Dirnhofer S, Clausen J, and Gastl G (2000) Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells. Lancet 355:1688-1691
Hayat MA (2002) Microscopy, immunohistochemistry, and antigen retrieval methods. Kluwer Academic/Plenum Publishers, New York
Hayat MA (ed) (2004-2006) Immunohistochemistry and in situ hybridization of human carcinomas, vols 1-4. Elsevier/Academic Press, San Diego, CA
Hicklin DJ, and Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011-1027
Jerkic M, Rivas-Elena JV, Prieto M, Carro R, Sanz-Rodriguez F, Perez-Barriocanal F, Rodriguez-Barbero A, Bernabeu C, Lopez-and Novoa JM (2004) Endoglin regulates nitric oxide-dependent vasodilatation. FASEB J 18:609-611
Lee SH, Mizutani N, Mizutani M, Luo Y, Zhou H, Kaplan C, Kim SW, Xiang R, and Reisfeld RA (2006) Endoglin (CD105) is a target for an oral DNA vaccine against breast cancer. Cancer Immunol Immunother 55:1565-1574
Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, and Wendel DP (1999) Defective angiogenesis in mice lacking endoglin. Science 284:1534-1537
Maier JAM, Delia D, Thorpe PE, and Gasparini G (1997) In vitro inhibition of endothelial cell growth by the anti-angiogenic drug AGM-1470 (TNP-460) and the anti-endoglin antibody TEC-11. Anticancer Drugs 8:238-244
Martone T, Rosso P, Albera R, Migliaretti G, Fraire F, Pignataro L, Pruneri G, Bellone G, and Cortesina G (2005) Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncol 41:147-155
Marx J (2007) Encouraging results for second-generation antiangiogenesis drugs. Science 308:1248-1249
Massi D, Franchi A, Paglierani M, Ketabchi S, Borgognoni L, Reali UM, and Santucci M (2004) Vasculogenic mimicry has no prognostic significance in pT3 and pT4 cutaneous melanoma. Hum Pathol 35:496-502
McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J, McCormick MK, Pericak-Vance MA, Heutink P, Oostra BA, Haitjema T, Westerman CJJ, Porteous ME, Guttmacher AE, Letarte M, and Mar-Chuk DA (1994) Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 8:345-351
Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, and Tokunaga O (2006a) Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. Virchows Arch 448:127-134
Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, and Tokunaga O (2006b) Organ-specific endoglin (CD105) expression in the angiogenesis of human cancers. Pathol Int 56:717-723
Ogawa A, Miyazaki K, and Tokunaga T (1999) Distribution of newly formed vessels in human colorectal carcinomas with microangiography. Colorec Dis 1:88-100
Okada K, Satoh T, Fujimoto K, and Tokunaga O (2004) Interaction between morphology and angiogenesis in human early colorectal cancers. Pathol Int 54:490-497
Saad RS, El-Gohary Y, Memari E, Liu YL, and Silverman JF (2005) Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in esophageal adenocarcinoma. Hum Pathol 36:955-961
Saito M, Sato Y, Watanabe J, Kuramoto H, Kabal S, and Fukuda T (2007) Angiogenic factors in normal endometrium and endometrial adenocarcinoma. Pathol Int 57:140-147
Shia S-R, Richard J, Cotea RJ, and Taylora CR (1997) Antigen retrieval immunohistochemistry: past, present, and future. J Histochem Cytochem 45:327-344
Takahashi N, Haba A, Matsuno F, and Seon BK (2001) Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin [CD105] monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res 61:7846-7854
Taskiran C, Erdem O, Onan A, Arisoy O, Acar A, Vural C, Erdem M, Ataoglu O, and Guner H (2006) The prognostic value of endoglin (CD105) expression in ovarian carcinoma. Int J Gynecol Cancer 16:1789-1793
Urness LD, Sorensen LK, and Li DY (2000) Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet 26:328-331
Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, Belien JA, de Waal RM, Van Marck E, Magnani E, Weidner N, Harris AL, and Dirix LY (2002) Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer 38:1564-1579
Wikstrom P, Lissbrant IF, Stattin P, Egevad L, and Bergh A (2002) Endoglin [CD105] is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate 51:268-275
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Tokunaga, O., Minhajat, R., Mori, D. (2010). Tumor Angiogenesis in Cancers: Expression of CD105 Marker. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3186-0_3
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DOI: https://doi.org/10.1007/978-90-481-3186-0_3
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