Abstract
Papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be a relatively genome stable neoplasm. In contrast to follicular thyroid carcinoma (FTC), almost all PTCs are diploid (Johannessen et al 1981). PTCs have been shown to be microsatellite stable (Soares et al 1997) and generally show low levels of loss of heterozygosity (Kitamura et al 2000; Gillespie et al 2000). The literature has shown that PTC is associated with several specific molecular genetic events, the best documented of which are ret/PTC rearrangements (REF) and the more recently described BRAF V600E mutation (Puxeddu et al 2004; Kimura et al 2003). Ret/PTC and BRAF mutations appear to largely occur in a mutually exclusive manner (Soares et al 2003). Activating point mutations of the RAS oncogene are also considered to account for the development of a small subset of adult sporadic PTCs (Namba et al 1990).
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Finn, S.P., O’Leary, J.J., Sheils, O.M. (2010). Papillary Thyroid Carcinoma: Detection of Copy Gain of Platelet Derived Growth Factor B Using Array Comparative Genomic Hybridization in Combination with Laser Capture Microdissection. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3186-0_26
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