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Regulation of Second Messenger Systems and Intracellular Pathways

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Book cover A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

Abstract

The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Pharmacology Section, University of Ferrara, 44100, Ferrara, Italy

    Stefania Merighi & Carolina Simioni

  2. Division of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, Leiden University, 9502, 2300, RA, Leiden, The Netherlands

    Rob Lane & Adriaan P. Ijzerman

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  1. Stefania Merighi
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  2. Carolina Simioni
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  3. Rob Lane
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  4. Adriaan P. Ijzerman
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Editors and Affiliations

  1. Ist. Farmacologia, Universita Ferrara, Via Fossato di Mortara 64 B, Ferrara, 44100, Italy

    Pier Andrea Borea

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Merighi, S., Simioni, C., Lane, R., Ijzerman, A.P. (2010). Regulation of Second Messenger Systems and Intracellular Pathways. In: Borea, P. (eds) A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3144-0_4

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