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Mechanistic Aspects of Fetal Development Relating to Postnatal Fibre Production and Follicle Development in Ruminants

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Managing the Prenatal Environment to Enhance Livestock Productivity

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Abstract

More than 50 years ago, it was noted that wool follicle development in sheep fetuses suffering growth restriction in utero (e.g. twin lambs or single lambs born to maiden ewes) was significantly impaired [105]. A little later, observations of the postnatal wool production performance in lambs from ewes undernourished during gestation indicated that restriction of fetal development had permanent effects upon wool follicle development and long-lasting effects upon postnatal wool fibre production [107]. Though not described in this way at the time, these were early indicators that programming of the fetus for development takes cues from the “maternal environment” during gestation. The cues can be in operation as early as the first few days in embryonic life and possibly earlier [69, 120]. Fetal programming, and influences on gene expression and ultimately development imposed upon the fetus in utero, has become a topic of increasing interest over the last decade. This is especially so since lifetime consequences of such programming have been demonstrated in humans [6, 73]. Perturbed fetal programming can occur through different mechanisms and the effects of one such mechanism, intra-uterine growth retardation (IUGR), on development of the progeny have been reported in many publications.

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Authors and Affiliations

  1. SARDI Livestock and Farming Systems, 5371, Roseworthy, SA, Australia

    C. Simon Bawden, David O. Kleemann, Clive J. McLaughlan, Gregory S. Nattrass & Stephanie M. Dunn

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  1. C. Simon Bawden
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  2. David O. Kleemann
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  4. Gregory S. Nattrass
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  5. Stephanie M. Dunn
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Correspondence to C. Simon Bawden .

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  1. NSW Department of Primary Industries, Trevenna Road, Armidale, 2351, Australia

    Paul L. Greenwood

  2. Livestock Industries, Queensland Bioscience Precinct, CSIRO, Carmody Rd. 306, St. Lucia, 4067, Australia

    Alan W. Bell

  3. Fac. Natural & Agricultural Sciences, School of Animal Biology, University of Western Australia, Crawley, 6009, Australia

    Philip E. Vercoe

  4. Agency (IAEA), Division of Nuclear Techniques in, International Atomic Energy, Wagramer Str. 5, Wien, 1400, Austria

    Gerrit J. Viljoen

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Bawden, C.S., Kleemann, D.O., McLaughlan, C.J., Nattrass, G.S., Dunn, S.M. (2009). Mechanistic Aspects of Fetal Development Relating to Postnatal Fibre Production and Follicle Development in Ruminants. In: Greenwood, P., Bell, A., Vercoe, P., Viljoen, G. (eds) Managing the Prenatal Environment to Enhance Livestock Productivity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3135-8_5

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