Abstract
Radiotherapy is one of the most effective modalities for the treatment of cancer. Is it possible to increase its effectiveness? It is well known that there is a high degree of uncertainty associated with the target volume of most cancer sites. The sources of these uncertainties include, but are not limited to, the uncertainty involved in the delivery of the therapeutical dose, the delineation of the target volume, patient setup errors, the motion of the target, and patient movements. Such uncertainties will always influence the accuracy of radiotherapy. It is assumed that this directly has an impact on the effectiveness of radiotherapy. In order to develop strategies to improve the accuracy and hence effectiveness of radiotherapy it is therefore first needed to assess required and achievable uncertainties of all steps involved. Only based on such data strategies for improvements can be developed.
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References
IAEA: Setting up a Radiotherapy Programme: Clinical, Medical Physics, Radiation Protection and Safety Aspects. STI/PUB/1296, Vienna, International Atomic Energy Agency, 2008 [www-pub.iaea.org/MTCD/publications/PDF/pub1296_web.pdf].
International Organization for Standardization: “Guide to the Expression of Uncertainty in Measurement”, 2nd edn, Geneva (1995).
Mijnheer BJ, Battermann JJ, Wambersie A: What degree of accuracy is required and can be achieved in photon and neutron therapy? Radiother Oncol 8, 237–252 (1987).
ACTA ONCOLOGICA, Suppl.1 (edited by Brahme A), Stockholm (1988).
IAEA International Atomic Energy Agency. “Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water”. Technical Report Series no. 398, IAEA, Vienna (2000).
Van Dyk J, Barnett R, Cygler J, Shragge P: Commissioning and quality assurance of treatment planning computers. Int J Radiat Oncol Biol Phys 26, 261–273 (1993).
Fraass B, Doppke K, Hunt M, Kutcher G, Starkschall G, Stern R, Van Dyke J: AAPM Radiation Therapy Committee Task Group 53: Quality assurance for clinical radiotherapy treatment planning. Med Phys 25, 1773–1829 (1998).
Kagawa K, Lee WR, Schultheiss TE, Hunt MA, Shaer AH, Hanks GE: Initial clinical assessment of CT-MRI image fusion software in localization of the prostate for 3D conformal radiation therapy. Int J Radiat Oncol Biol Phys 38, 319–325 (1997).
Rasch C, Keus R, Pameijer FA, Koops W, de Ru V, Muller S, Touw A, Bartelink H, van Herk M, Lebesque JV: The potential impact of CT-MRI matching on tumor volume delineation in advanced head and neck cancer. Int J Radiat Oncol Biol Phys 39, 841–848 (1997).
Senan S, van Sörnsen de Koste J, Samson M, Tankink H, Jansen P, Nowak PJ, Krol AD, Schmitz P, Lagerwaard FJ: Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer. Radiother Oncol. 53, 247–255 (1999).
van Herk M, Remeijer P, Rasch C, Lebesque JV: The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys 47, 1121–1135 (2000).
Langen KM, Jones DT: Organ motion and its management. Int J Radiat Oncol Biol Phys 50, 265–278 (2001).
ICRU International Commission on Radiation. Determination of absorbed dose in a patient irradiated by beams of X or gamma rays in radiotherapy procedures. ICRU Report 24, ICRU, Bethesda (1976).
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Hartmann, G.H. (2009). Accuracy Strategies in Radiotherapy. In: Lemoigne, Y., Caner, A. (eds) Radiotherapy and Brachytherapy. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3097-9_2
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DOI: https://doi.org/10.1007/978-90-481-3097-9_2
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