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“One for All” or “All for One”? – The Necessity of Cancer Stem Cell Diversity in Metastasis Formation and Cancer Relapse

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Stem Cell Biology in Health and Disease

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Abstract

Cancer stem cells (CSCs) are a rare population of cancer cells exhibiting stem cell properties, such as self-renewal, differentiation and tissue restoration. Because of the latter stem cell feature it is now assumed that (i) tumors originate from CSCs and (ii) that tumor tissues are organized hierarchically like normal tissues. Due to their tumor-initiating capacity as well as their inherent resistance towards radiation and cytotoxic compounds because of expression of multidrug resistance transporters and a highly efficient DNA repair system, CSCs have also been linked to metastatic spreading and cancer relapses. However, to initiate secondary lesions, CSCs must be capable to fulfill the hallmarks of metastasis formation and should be responsive to those factors facilitating organ-specific metastatic spreading. Additionally, cancer relapses exhibit an increased drug resistance and are often more aggressive than the original tumor. This suggest the necessity and existence of different CSC subtypes. In the present chapter, we will discuss whether different, cancer stage specific CSCs exist and if, how these particular cell types might originate.

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Acknowledgments

This work was supported by the “Verein zur Förderung der Krebsforschung e.V.”, Heidelberg, Germany and the Fritz-Bender-Foundation, Munich, Germany.

Author information

Authors and Affiliations

  1. Institute of Immunology, Faculty of Medicine, Witten/Herdecke University, Alfred-Herrhausenstr. 50, 58448, Witten, Germany

    Thomas Dittmar

  2. Institute of Immunology, Witten/Herdecke University, 58448, Witten, Germany

    Christa Nagler, Kathrin Krause, Georg Reith, Bernd Niggemann & Kurt S. Zänker

  3. Klinikum rechts der Isar, Second Department of Medicine, Technical University of Munich, 81675, Munich, Germany

    Sarah Schwitalla

  4. Medizinische Klinik II m. S. Hämatologie/Onkologie Charité Campus Mitte, 10117, Berlin, Germany

    Jeanette Seidel

Authors
  1. Thomas Dittmar
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  2. Christa Nagler
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  3. Sarah Schwitalla
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  4. Kathrin Krause
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  5. Jeanette Seidel
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  6. Georg Reith
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  7. Bernd Niggemann
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  8. Kurt S. Zänker
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Corresponding author

Correspondence to Thomas Dittmar .

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Editors and Affiliations

  1. Inst. Immunologie, Universität Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Thomas Dittmar

  2. Inst. Immunologie, Universität Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Kurt S. Zanker

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© 2009 Springer Science+Business Media B.V.

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Dittmar, T. et al. (2009). “One for All” or “All for One”? – The Necessity of Cancer Stem Cell Diversity in Metastasis Formation and Cancer Relapse. In: Dittmar, T., Zanker, K. (eds) Stem Cell Biology in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3040-5_15

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