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The Chronically Inflamed Microenvironment and Cancer Stem Cells

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Stem Cell Biology in Health and Disease

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Abstract

The notion that tumors contain a population of cells termed cancer stem cells, or cancer initiating cells has been gaining momentum over the past several years. It is postulated that much like a normal organ in the body, tumors contain a population of stem cells which are responsible for driving tumor growth, invasion and metastasis. This becomes of paramount clinical importance because our present therapies often times shrink tumors, but do not prevent their recurrence or metastatic spread. This behavior of tumors suggests that a population of cells within the tumor capable of driving tumor growth is insensitive to our current therapies and survives to reestablish disease. Therefore, understanding the biology of the cancer stem cell which is believed responsible for this tumor re-growth, will allow targeted therapy to better treat cancers. This chapter reviews the cancer stem cell hypotheses, and investigates the potential sources for the cancer stem cell.

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Authors and Affiliations

  1. Department of Medicine and Cancer Biology, University of Massachusetts Medical School, 01536, Worcester, MA, USA

    Hanchen Li, Calin Stoicov, Xueli Fan, Jan Cerny & Jean Marie Houghton

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  1. Hanchen Li
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  2. Calin Stoicov
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  3. Xueli Fan
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  4. Jan Cerny
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  5. Jean Marie Houghton
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Correspondence to Jean Marie Houghton .

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  1. Inst. Immunologie, Universität Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Thomas Dittmar

  2. Inst. Immunologie, Universität Witten/Herdecke, Stockumer Str. 10, Witten, 58448, Germany

    Kurt S. Zanker

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Li, H., Stoicov, C., Fan, X., Cerny, J., Houghton, J.M. (2009). The Chronically Inflamed Microenvironment and Cancer Stem Cells. In: Dittmar, T., Zanker, K. (eds) Stem Cell Biology in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3040-5_11

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