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Stem Cell Niche Versus Cancer Stem Cell Niche – Differences and Similarities

  • Bruce C. Baguley
  • Graeme J. Finlay
Chapter

Abstract

The organization of normal tissues and organs is thought to be based on stem cells, which are present as a small proportion of the total tissue. Stem cells in turn absolutely require supporting structures to maintain their self-renewal properties and such structures are termed niches. A large amount of evidence now supports the concept that tumors are also maintained by tumor stem cells, and by implication such cells will be contained within tumor stem cell niches. In this review we explore the hypothesis that the transition of the normal niche to the tumor niche occurs over a significant period of time and that different intermediate stages, termed here the “inflammatory niche” and the “immunological niche”, can be discerned. The inflammatory niche provides a chronic stress stimulus which causes an increased rate of stem cell proliferation while the immunological niche provides mechanisms to inhibit the proliferation of potential tumor cells that have formed in the inflammatory niche. The tumor cell niche therefore represents the ultimate breakdown of such proliferation control.

Keywords

Stem cell Niche Chronic inflammation Tumor fibroblasts Lymphocytes Macrophages Cell cycle arrest Tumor dormancy TGF-β Interferon-γ 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Auckland Cancer Society Research CentreThe University of AucklandAucklandNew Zealand

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