Within the past years our knowledge about stem cell biology in health and disease has changed dramatically. What rather sounded like Science Fiction 10–15 years ago, namely that e.g., stem cells from bone marrow or from adipose tissues can be used for regenerative medical approaches, or that it is possible to create donor specific stem cells (so-called induced pluripotent stem cells (iPS cells), exhibiting embryonic stem cell (ESC) properties) simply by transducing 2–4 transcription factors, has now become reality. Likewise, the knowledge that cancer tissues are hierarchically organized like normal tissues, namely comprising of a small amount of tumorigenic cancer stem cells (CSCs) and a huge mass of non-tumorigenic cancer cells will play a crucial role in the development of novel anti-cancer strategies.
KeywordsStem Cell Adult Stem Cell Stem Cell Biology Stem Cell State Bone Marrow Reconstitution
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