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Mycobacterial Heat Shock Protein 60s in the Induction and Regulation of Infectious Disease

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Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease

Part of the book series: Heat Shock Proteins ((HESP,volume 4))

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Abstract

Mycobacterium tuberculosis expresses several heat shock protein 60s, also called chaperonin 60 proteins. As well as being protein folding molecules, the chaperonin 60 proteins have implications in bacterial diseases. Here we discuss the effect of the mycobacterial chaperonins in the regulation of tuberculosis. The disease is characterized by the formation of granulomas, which are necessary for completing the life cycle of bacteria. The mycobacterial chaperonins are released into the cellular environment and are potent pro-inflammatory inducers. An M. tuberculosis mutant lacking the chaperonin 60.1 is not capable of inducing the granulomas in vivo. In vitro data also suggest an inhibitory role of mycobacterial chaperonins. Taken together, the mycobacterial chaperonin 60 proteins may control the immune responses during the tuberculosis infection.

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Authors and Affiliations

  1. Medical Microbiology, Centre for Infection, Department of Cellular and Molecular Medicine, St George’s University of London, SW17 ORE, London, UK

    Anthony R.M. Coates, Ana Cehovin & Yanmin Hu

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  1. Anthony R.M. Coates
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  2. Ana Cehovin
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  3. Yanmin Hu
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Correspondence to Anthony R.M. Coates .

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Editors and Affiliations

  1. School of Medicine & Biomedical Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom

    A. Graham Pockley

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Burlington Avenue 21-27, Boston, 02215, U.S.A.

    Stuart K. Calderwood

  3. Dipto. Biologia, Università di Roma, Tor Vergata, Via della Ricerca Scientifica 1, Roma, 00133, Italy

    M. Gabriella Santoro

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Coates, A.R., Cehovin, A., Hu, Y. (2009). Mycobacterial Heat Shock Protein 60s in the Induction and Regulation of Infectious Disease. In: Pockley, A., Calderwood, S., Santoro, M. (eds) Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease. Heat Shock Proteins, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2976-8_6

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