Abstract
Malignant melanoma is known to display a tremendous histologic diversity. Expe-rience has shown that biomarkers determined in research laboratories can be adapted to everyday histopathology routine. However, the present immunohistochemical markers are not applicable for differentiation between malignant melanoma and melanocytic borderline lesions mimicking melanoma, such as dysplastic nevus, Spitz nevus or deep penetrating nevus (Roesch et al. 2006a). Thus, we intended to discriminate true malignant tumor progression from invasive, but non-metastasizing melanocytic growth applying our recently established algorithm for immunohistochemical marker evaluation (Roesch et al. 2005a, b, 2006b). This new approach could be helpful for further studies, because it allows straightforward and exact histo-morphologic assessment of candidate markers.
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Roesch, A., Landthaler, M., Vogt, T. (2010). Malignant Melanoma Versus Deep Penetrating Nevus: Diagnostic and Prognostic Immunohistochemistry of Dipeptidyl Peptidase IV (Methodology). In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2918-8_27
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