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The calcitonin gene-related peptide family pp 131–149Cite as

Insights into the Function of Intermedin/Adrenomedullin 2

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Abstract

The hypothalamus/pituitary axis is central to the regulation of neuroendocrine homeostasis in vertebrates. Based on homologous searches of genome sequences, our laboratory and that of Dr. Y. Takei independently discovered intermedin (also known as adrenomedullin 2) as a novel calcitonin/CGRP/amylin/adrenomedullin family peptide. Intermedin is expressed in a variety of tissues and signals through the CLR/RAMP receptor complexes. In addition to having potent effects on the cardiovascular system, intermedin exhibits unique functional characteristics in the regulation of neuroendocrine system and pituitary hormone secretion. Based on physiological and molecular analyses, we proposed that in the pituitary intermedin could function as a prolactin-releasing factor participating in the estrogen-regulated prolactin release during reproduction. While the exact physiological role and the therapeutic potential of this novel peptide remain to be analyzed, recently progress has pointed to pleiotropic roles in diverse physiological systems in humans and other vertebrates.

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Abbreviations

ACTH:

adrenocorticotropic hormone

ADM:

adrenomedullin

CGRP:

calcitonin gene related peptide

CLR:

calcitonin receptor-like receptor

CRF:

corticotropin releasing factor

GPCR:

G protein-coupled receptor

IMD:

intermedin

MSH:

melanocyte-stimulating hormone

NOS:

nitric oxide synthase

POMC:

proopiomelanocortin

RAMP:

receptor activity modifying protein.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital, Tao-Yuan, 333, Taiwan

    Chia Lin Chang

  2. Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Dr., Boswell Building, Room A344D, Stanford, CA, 94305-5317, USA

    Sheau Yu Teddy Hsu

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  1. Chia Lin Chang
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  2. Sheau Yu Teddy Hsu
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Correspondence to Chia Lin Chang .

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Editors and Affiliations

  1. School of Biological Sciences, University of Auckland, Symonds St. 9, Auckland , 1142, New Zealand

    Deborah L. Hay

  2. University of Auckland, Symonds Street 3A, Auckland, 1142, New Zealand

    Ian M. Dickerson

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Chang, C.L., Hsu, S.Y.T. (2010). Insights into the Function of Intermedin/Adrenomedullin 2. In: Hay, D., Dickerson, I. (eds) The calcitonin gene-related peptide family. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2909-6_9

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