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Solid Forms of Pharmaceutical Molecules

  • Bohumil KratochvílEmail author
Chapter
Part of the Hot Topics in Thermal Analysis and Calorimetry book series (HTTC, volume 8)

Abstract

A drug discovery is characterized by two stages. The first in terms of time is called “lead structure”, followed by a so called “drug candidate” stage. The lead structure stage involves selecting the optimum molecule of the pharmaceutical, while drug candidate stage means selecting the optimum solid form. Usually, five to ten candidates pass to the drug candidate stage and the result is the selection of the final solid API (Active Pharmaceutical Ingredience) for the ensuing formulation of the solid dosage form. The lead structure stage concerns only the discovery of the original drug, the drug candidate stage may concern also generics (a drug which is bioequivalent with original and is produced and distributed after the patent protection of the original).

Keywords

Ergot Alkaloid Mandelic Acid Pharmaceutical Substance Stable Polymorph Patent Litigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This chapter was written in the framework of the project MSM 2B08021 of the Ministry of Education of the Czech Republic.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Prague Institute of Chemical TechnologyPraha 6Czech Republic

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