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Interactomics and Cancer

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An Omics Perspective on Cancer Research

Abstract

Cancer is a complex disease with a myriad of genes and molecular processes involved. To unravel its underlying mechanisms, the main approach to date has been the study of individual genes and their association with carcinogenesis. As a recently emerging new paradigm, systems biology has complemented this time-honoured concept by promoting a holistic view of cancer as a network-associated disease. This new strategy is reflected par excellence by the construction of genome- and proteome-wide interaction networks and their utilization. We give here an overview of the current status of the human interactome and report first successes in its application in cancer research. In particular, interactomics-based analyses have been successfully undertaken for the characterization and de novo prediction of cancer-associated genes and processes. Although considerable challenges are still to overcome, interactomics promises to become a cornerstone in the systems biology of cancer.

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Acknowledgements

We would like to thank Paulo Martel and Nuno dos Santos for their important contributions to this chapter.

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Authors and Affiliations

  1. Charité, Humboldt-University, Berlin, Germany

    Gautam Chaurasia

  2. Centre for Molecular and Structural Biomedicine, University of Algarve, Faro, Portugal

    Matthias E. Futschik

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  1. Gautam Chaurasia
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  2. Matthias E. Futschik
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Correspondence to Matthias E. Futschik .

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Editors and Affiliations

  1. Dept. Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Kowloon, Hong Kong/PR China

    William C.S. Cho

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Chaurasia, G., Futschik, M.E. (2010). Interactomics and Cancer. In: Cho, W. (eds) An Omics Perspective on Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2675-0_9

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