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The Roles of SUMO in Metabolic Regulation

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SUMO Regulation of Cellular Processes

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Abstract

Protein modification with the small ubiquitin-related modifier (SUMO) can affect protein function, enzyme activity, protein-protein interactions, protein stability, protein targeting and cellular localization. SUMO influences the function and/or regulation of metabolic enzymes within pathways, and in some cases targets entire metabolic pathways by affecting the activity of transcription factors or by facilitating the translocation of entire metabolic pathways to subcellular compartments. SUMO modification is also a key component of nutrient- and metabolic-sensing mechanisms that regulate cellular metabolism. In addition to its established roles in maintaining metabolic homeostasis, there is increasing evidence that SUMO is a key factor in facilitating cellular stress responses through the regulation and/or adaptation of the most fundamental metabolic processes, including energy and nucleotide metabolism. This review focuses on the role of SUMO in cellular metabolism and metabolic disease.

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Abbreviations

SUMO:

Small Ubiquitin-related Modifier

SIM:

SUMO interacting motif

SREBPs:

sterol regulatory element binding proteins

bHLH-Zip:

basic helix-loop-helix leucine zipper

SRE:

sterol response element

SCAP:

SREBP cleavage-activating protein

INSIG:

insulin inducing gene

MAPKs:

mitogen-activated protein kinases

HDAC3:

histone deacetylase 3

ROS:

reactive oxygen species

SENPs:

sentrin specific proteases

PPARs:

peroxisome proliferators-activated receptors

KLF5:

Krüppel like transcription factor 5

Cpt1b:

carnitine palmitoyl transferase

Ucp2:

uncoupling proteins

ICA512:

islet cell autoantigen 512

STAT5:

signal transducer and activator of transcription

GLUTs:

glucose transporters

DRP1:

dynamin related protein 1

FIS1:

fission protein 1

MTHFD1:

methylenetetrahydrofolate dehydrogenase 1

SHMT1:

serine hydroxymethyltransferase 1

TYMS:

thymidylate synthase

DHFR:

dihyrdofolate reductase

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Authors and Affiliations

  1. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA

    Donald D. Anderson & Patrick J. Stover

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  1. Donald D. Anderson
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  2. Patrick J. Stover
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Correspondence to Patrick J. Stover .

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Editors and Affiliations

  1. College Station, 77843-1114, U.S.A.

    Van G. Wilson

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Anderson, D.D., Stover, P.J. (2009). The Roles of SUMO in Metabolic Regulation. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2649-1_8

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