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The Role of Sumoylation in Neurodegenerative Diseases

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SUMO Regulation of Cellular Processes

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Abstract

The covalent posttranslational modification of proteins are critical events in signalling cascades that enable cells to efficiently, rapidly and reversibly respond to extracellular stimuli. This is especially important in the CNS where the processes affecting synaptic communication between neurons are highly complex and very tightly regulated. Sumoylation regulates the function and fate of a diverse array of proteins and participates in the complex cell signalling pathways required for cell survival. One of the most complex signalling pathways is synaptic transmission. Correct synaptic function is critical to the working of the brain and its alteration through synaptic plasticity mediates learning, mental disorders and stroke. The investigation of neuronal sumoylation is a new and exciting field and the functional and pathophysiological implications are far-reaching. Sumoylation has already been implicated in a diverse array of neurological disorders. Here we provide an overview of current literature highlighting recent insights into the role of sumoylation in neurodegeneration. In addition we present a brief assessment of drug discovery in the analogous ubiquitin system and extrapolate on the potential for development of novel therapies that might target SUMO-associated mechanisms of neurodegenerative disease.

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Acknowledgements

Dina Anderson is a PhD student funded by UCB Pharm S.A. We thank Kevin Wilkinson for a critical reading of the manuscript. We are grateful to the Wellcome Trust, BBSRC, MRC and the European Research Council for financial support.

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  1. MRC Centre for Synaptic Plasticity, Department of Anatomy, University Walk, University of Bristol, BS8 1TD, Bristol, UK

    Dina B. Anderson, Helena Cimarosti & Jeremy M. Henley

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  1. Dina B. Anderson
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    Van G. Wilson

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Anderson, D.B., Cimarosti, H., Henley, J.M. (2009). The Role of Sumoylation in Neurodegenerative Diseases. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2649-1_14

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