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Sumoylation and Apoptosis

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SUMO Regulation of Cellular Processes

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Abstract

Apoptosis is a physiological mechanism to maintain human tissues or cells, and pathological dysfunction of this process explains some disease states or drug resistance. P53, mdm2, sumoylation, signal transduction, and transcriptional control are important in regulation in cancer cells. We focus on the mechanisms of apoptosis in cancer cells involving SUMO.

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References

  • Babic, I., Cherry, E. and Fujita, D. J., 2006, SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosis. Oncogene 25, 4955–4964.

    Article  PubMed  CAS  Google Scholar 

  • Bischof, O., Schwamborn, K., Martin, N., Werner, A., Sustman, C., Grosschendl, R. and Dejean, A., 2006, The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol. Cell 22, 783–794.

    Article  PubMed  CAS  Google Scholar 

  • Buschmann, T., Fuchs, S. Y., Lee, C. G., Pan, Z. Q. and Ronai, Z., 2000, SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell 101, 753–762.

    Article  PubMed  CAS  Google Scholar 

  • Carvajal, D., Tovar, C., Yang, H., Vu, B. T., Heimbrook, D. C and Vassilev, L. T., 2005, Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res. 65, 1918–1924.

    Article  PubMed  CAS  Google Scholar 

  • Coll-Mulet, L., Iglesias-Serret, D., Santidrián, A. F., Cosialls, A. M., de Frias, M., Castano, E., Campas, C., Barragan, M., de Sevilla, A. F., Domingo, A., Vassilev, L. T., Pons, G. and Gil, J., 2006, MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. Blood 107, 4109–4114.

    Article  PubMed  CAS  Google Scholar 

  • Efeyan, A., Ortega-Molina, A., Velasco-Miguel, S., Herranz, D., Vassilev, L. T. and Serrano, M., 2007, Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res. 67, 7350–7357.

    Article  PubMed  CAS  Google Scholar 

  • Ennishi, D., Yokoyama, M., Terui, Y., Asai, H., Sakajiri, S., Mishima, Y., Takahashi, S., Komatsu, H., Ikeda, K., Takeuchi, K., Tanimoto, M. and Hatake, K., 2009, Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy. Ann. Oncol. 20, 526–533.

    Article  PubMed  CAS  Google Scholar 

  • Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y. G., Chang, C., Hopp, T., Fuqua, S. A., Jaffray, E., Hay, R. T., Palvimo, J. J., Janne, O. A. and Pestell, R. G., 2002, Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol. Cell. Biol. 22, 3373–3388.

    Article  PubMed  CAS  Google Scholar 

  • Huang, T. T., Wuerzberger-Davis, S. M., Wu, Z. H. and Miyamoto, S., 2003, Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115, 565–576.

    Article  PubMed  CAS  Google Scholar 

  • Janz, M., Stühmer, T., Vassilev, L. T. and Bargou, R. C., 2007, Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells. Leukemia 21, 772–779.

    PubMed  CAS  Google Scholar 

  • Jennewein, C., Kuhn, A. M., Schmidt, M. V., Meilladec-Jullig, V., von Knethen, A., Gonzalez, F. J. and Brune, B., 2008, Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J. Immunol. 181, 5646–5652.

    PubMed  CAS  Google Scholar 

  • Kojima, K., Konopleva, M., Samudio, I. J., Shikami, M., Cabreira-Hansen, M., McQueen, T., Ruvolo, V., Tsao, T., Zeng, Z., Vassilev, L. T. and Andreeff, M., 2005, MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood 106, 3150–3159.

    Article  PubMed  CAS  Google Scholar 

  • Lee, P. S., Chang, C., Liu, D. and Derynck, R., 2003, Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. J. Biol. Chem. 278, 27853–27863.

    Article  PubMed  CAS  Google Scholar 

  • Lee, Y. S., Jang, M. S., Lee, J. S., Choi, E. J. and Kim, E., 2005, SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification. EMBO Rep. 6, 949–955.

    Article  PubMed  CAS  Google Scholar 

  • Mao, Y., Sun, M., Desai, S. D. and Liu, L. F., 2000. SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc. Natl. Acad. Sci. U.S.A. 97, 4046–4051.

    Article  PubMed  CAS  Google Scholar 

  • Meinecke, I., Cinski, A., Baier, A., Peters, M. A., Dankbar, B., Wille, A., Drynda, A., Mendoza, H., Gay, R. E., Hay, R. T., Ink, B., Gay, S. and Pap, T., 2007, Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 104, 5073–5078.

    Article  PubMed  CAS  Google Scholar 

  • Muromoto, R., M. Ishida, K. Sugiyama, Y. Sekine, K. Oritani, K. Shimoda, and Matsuda, T., 2006. Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation. J. Immunol. 177, 1160–1170.

    Google Scholar 

  • Poukka, H., Karvonen, U., Janne, O. A. and Palvimo, J. J., 2000, Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc. Natl. Acad. Sci. U.S.A. 97, 14145–14150.

    Article  PubMed  CAS  Google Scholar 

  • Stühmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R. A., Daniel, P. T., Bommert, K., Vassilev, L. T. and Bargou, R. C., 2005, Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma. Blood 106, 3609–3617.

    Article  PubMed  Google Scholar 

  • Utsubo-Kuniyoshi, R., Terui, Y., Mishima, Y., Rokudai, A., Mishima, Y., Sugimura, N., Kojima, K., Sonoda, Y., Kasahara, T. and Hatake, K., 2007, MEK-ERK is involved in SUMO-1 foci formation on apoptosis. Cancer Sci. 98, 569–576.

    Article  PubMed  CAS  Google Scholar 

  • Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., Fotouhi, N. and Liu, E. A., 2004, In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844–848.

    Article  PubMed  CAS  Google Scholar 

  • Wasiak, S., Zunino, R. and McBride, H. M., 2007, Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J. Cell Biol. 177, 439–450.

    Article  PubMed  CAS  Google Scholar 

  • Yang, Y., Ludwig, R. L., Jensen, J. P., Pierre, S. A., Medaglia, M. V., Davydov, I. V., Safiran, Y. J., Oberoi, P., Kenten, J. H., Phillips, A. C., Weissman, A. M. and Vousden, K. H., 2005, Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7, 547–559.

    Article  PubMed  CAS  Google Scholar 

  • Zunino, R., Schauss, A., Rippstein, P., Andrade-Navarro, M. and McBride, H. M., 2007, The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J. Cell Sci. 120, 1178–1188.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Chemotherapy and Olympus Bio-Imaging Laboratory, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, 135-8550, Koto-ku, Tokyo, Japan

    Kiyohiko Hatake, Ryoko Kuniyoshi, Yuko Mishima & Yasuhito Terui

Authors
  1. Kiyohiko Hatake
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  2. Ryoko Kuniyoshi
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  3. Yuko Mishima
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  4. Yasuhito Terui
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Correspondence to Kiyohiko Hatake .

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Editors and Affiliations

  1. College Station, 77843-1114, U.S.A.

    Van G. Wilson

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© 2009 Springer Science+Business Media B.V.

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Hatake, K., Kuniyoshi, R., Mishima, Y., Terui, Y. (2009). Sumoylation and Apoptosis. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2649-1_13

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