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Pathogenesis of Invasive Pulmonary Aspergillosis

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Abstract

The study of the pathogenesis of invasive pulmonary aspergillosis has advanced significantly over recent years because of scientific achievements on two fronts: sequencing of the genomes of three Aspergillus species and elucidation of the innate immune mechanisms involved in defence against Aspergillus infection. The principal events that lead to invasive aspergillosis take place in the alveolus, where inhaled conidia germinate into invading hyphae that penetrate the respiratory epithelium. Pulmonary innate immunity against Aspergillus infection consists of resident and recruited phagocytes, soluble immune factors, and antimicrobial proteins. Various Aspergillus traits, including the production of pigment, antioxidants, proteases, adhesins, siderophores, and mycotoxins, are implicated as potential virulence factors. The complex interplay amongst these factors, usually in the setting of depressed immunity, forms the basis for this medically important opportunistic mycosis.

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Authors and Affiliations

  1. Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Ronen Ben-Ami

  2. Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 77030, Houston, TX, USA

    Dimitrios P. Kontoyiannis

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  1. Ronen Ben-Ami
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  2. Dimitrios P. Kontoyiannis
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Correspondence to Dimitrios P. Kontoyiannis .

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  1. Porto Alegre, Complexo Hospitalar Santa Casa de, Av. Independencia 155, Porto Alegre, 90035-075, Brazil

    Alessandro Comarú Pasqualotto

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Ben-Ami, R., Kontoyiannis, D.P. (2009). Pathogenesis of Invasive Pulmonary Aspergillosis. In: Comarú Pasqualotto, A. (eds) Aspergillosis: From Diagnosis to Prevention. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2408-4_21

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