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Molecular and Imaging Genetic Markers in Panic Disorder

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The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes

The authors give an overview of the present state of knowledge on the genetics of panic disorder. The relevant findings from clinical and molecular genetic studies, interaction analyses as well as meta-analyses of single association studies are presented in detail with particular emphasis on candidate genes involved in the serotonergic, noradrenergic and dop-aminergic system, such as the catechol-O-methyltrans-ferase (COMT) and the serotonin receptor 1A (5-HT1A) genes. An additional special focus will be on the adenosine receptor 2A (A2A) gene, which has been found to be associated with panic disorder and also with anxiety levels after caffeine administration in a gene—environment interactional model.

Finally, the first imaging genetic findings in panic disorder as published by the authors using fMRI techniques in combination with molecular genetic association analyses are reviewed, taking into account the present intermediate phenotype discussion in the investigation of complex genetic disorders.

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Authors and Affiliations

  1. Department of Psychiatry, University of Münster, Münster, Germany

    Katharina Domschke (Head of Group “Genetics of Affective Disorders”)

  2. Department of Psychiatry, University of Würzburg, Würzburg, Germany

    Jürgen Deckert (Full Professor and Chairman)

Authors
  1. Katharina Domschke
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  2. Jürgen Deckert
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Editors and Affiliations

  1. Israel Institute of Technology, Haifa

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

  2. Sha'ar Menashe Mental Health Center, Hadera, Israel

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

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Domschke, K., Deckert, J. (2009). Molecular and Imaging Genetic Markers in Panic Disorder. In: Ritsner, M.S. (eds) The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2298-1_8

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