It is now well established that many cancer patients exhibit in vivo and in vitro evidence of immune suppression, which often correlates with tumor-cell burden, stage of disease, and prognosis. Except in transplantation associated cancers, cancer-associated immune suppression appears to be a direct result of the presence of disease, or follows treatment for it, rather than being an antecedent or predisposing condition. However, the precise role that nonspecific and/or specific antitumor immunity plays in the control of human cancer remains controversial. Indeed, there is some evidence that suggests that the development of certain immune responses may lead to augmented tumor cell growth rather than tumor regression [178, 287, 406, 407, 582].
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Acknowledgments
Dr. Richard Schulof co-authored this chapter in the second edition, but died in an automobile accident during the preparation of the third edition.
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Oldham, R.K. (2009). Therapeutic approaches to cancer-associated immune suppression. In: Oldham, R.K., Dillman, R.O. (eds) Principles of Cancer Biotherapy. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2289-9_6
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