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Pancreas

  • Chapter
Human Adult Stem Cells

Part of the book series: Human Cell Culture ((HUCC,volume 7))

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Abstract

Type 1 diabetes and some forms of type 2 diabetes are caused by deficiency of insulin-secretory islet β cells. Although diabetes may be treated with exogenous insulin replacement, this is not a cure, and this therapy may be associated with some devastating complications, such as nephropathy, retinopathy and neuropathy. An ideal treatment for diabetes would be to transplant donated islets or to regenerate endogenous β cells. However, the poor availability of donor islets has severely restricted the broad clinical use of islet transplantation. The ability to differentiate embryonic stem cells into insulin-expressing cells initially showed great promise, but the generation of functional β cells has proven extremely difficult and far slower than originally thought. Pancreatic stem cells (PSC) or transdifferentiation of other cell types in the pancreas may therefore provide an alternative renewable source of surrogate β cells.

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Authors and Affiliations

  1. Western Australian Institute for Medical Research, Centre for Diabetes Research, and Centre for Medical Research, University of Western Australia, 50 Murray St (Rear), Perth, WA 6000, Australia

    Fang-Xu Jiang

  2. Western Australian Institute for Medical Research, and Centre for Medical Research, Centre for Diabetes Research, The University of Western Australia, Perth 6000, Australia

    Grant Morahan

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Editors and Affiliations

  1. University College London Inst. Urology & Nephrology, 67 Riding House Street, London, United Kingdom W1P 7PN

    John R. Masters

  2. Dept. Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0412, USA

    Bernhard Ø. Palsson

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Jiang, FX., Morahan, G. (2009). Pancreas. In: Masters, J.R., Palsson, B.Ø. (eds) Human Adult Stem Cells. Human Cell Culture, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2269-1_9

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