Abstract
The excessive hyperventilation seen during exercise in chronic heart failure (CHF) contributes to the limited exercise capacity in this condition. The hyperactivation of reflexes originating, independently, from muscle (ergoreflex) and from chemoreceptors (chemoreflex) has been suggested to play an important part in the mediation of the CHF ventilatory abnormalities. In this study we aimed to assess the ventilatory responses to the combined activation of the muscle ergoreflex and the ventilatory chemoreflex, achieved by post-exercise circulatory occlusion (PECO) and euoxic hypercapnia (end-tidal PCO2 = 7 mmHg above normal), respectively.
Three healthy women and three healthy men (29.33 ± 1.28 yrs; mean ± SD) undertook four trials, in random order, separated from each other by 30 min of rest: 2 min of isometric handgrip exercise followed by 2 min of PECO with hypercapnia, 2 min of isometric handgrip exercise followed by 2 min of PECO while breathing room air, 4 min of rest with hypercapnia and 4 min of rest while breathing room air.
Ventilation (VE) was significantly elevated by the ventilatory chemoreflex and it was further elevated by 5.13±0.83 L/min (P<0.05) when the muscle ergoreflex was superimposed upon it. The response to the combination of these stimuli was significantly greater than the sum of the responses to the two stimuli when given independently (P<0.05).
The results indicate that the interaction between the two reflexes has an additional stimulatory effect on ventilation and consequently could be involved in the limited exercise capacity in CHF.
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Lykidis, C., Kumar, P., Balanos, G. (2009). The Respiratory Responses to the Combined Activation of the Muscle Metaboreflex and the Ventilatory Chemoreflex. In: Gonzalez, C., Nurse, C.A., Peers, C. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 648. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2259-2_32
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DOI: https://doi.org/10.1007/978-90-481-2259-2_32
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