The Clinical Significance of Lymph-Node Metastasis

Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 13)


Lymph nodes are the initial site of metastasis in many cancers. For patients with clinically localized tumors, the pathologic status of regional nodes is the most important prognostic variable, and techniques to evaluate these nodes radiographically and surgically are critical components in management. Advances in nodal evaluation, particularly sentinel node biopsy, have enabled more accurate nodal evaluation with less morbidity. The therapeutic impact of lymph node dissection remains a subject of controversy in several solid tumors, but growing evidence suggests that early removal of microscopically involved lymph nodes improves the long-term outcome of patients. Nodal metastasis should remain a central focus of clinical research to build on these recent discoveries.

Key words

Lymph nodes metastases Prognosis Lymph node staging Lymph node imaging Lymph node dissection 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Division of Surgical Oncology, The Roy E. Coats Research LaboratoriesJohn Wayne Cancer Institute, Saint John’s Health CenterSanta MonicaUSA

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