New Animal Models of Lymphangiogenesis

Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 13)


The discovery of new genes, genetic pathways and drug targets involved in the formation of lymphatic vessels and capillaries has long been hampered by the absence of a small model organism amenable to large scale genetic and pharmacological screening. The recent description of functional and conserved lymphatic vascular systems in the two small animal models Xenopus laevis (the African clawed frog) and Danio rerio (the zebrafish) now opens up the possibility to exploit these models for the study of developmental lymphangiogenesis. In this chapter we will describe the discovery and characterisation of the lymphatic vasculature in both frog and fish models. We will also describe and compare the available genetic tools for the study of lymphangiogenesis in these new model systems.

Key words

Lymphatic Vasculature Lymphangiogenesis Zebrafish Xenopus 


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© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Hubrecht Institute (KNAW), University Medical Center UtrechtUtrechtThe Netherlands

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