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Apoptosis and Autophagy Cell Engineering

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Cell Line Development

Part of the book series: Cell Engineering ((CEEN,volume 6))

Abstract

Programmed cell death (apoptosis and autophagy) in cell cultures is considered an important problem to be dealt with as it affects the viable cell concentration and the product quality. This chapter describes various strategies employed to confront and prevent programmed cell death in biotechnologically important mammalian cell lines, mainly Chinese Hamster Ovary (CHO) cells, with special importance to the genetic manipulation of cells for anti-apoptosis and anti-autophagic engineering.

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Authors and Affiliations

  1. Department of Biological Sciences, KAIST, 335 Gwahangno, Yuseong-Gu, Daejeon, 305-701, Republic of Korea

    Chaya Mohan, Yeon-Gu Kim & Gyun Min Lee

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  1. Chaya Mohan
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  2. Yeon-Gu Kim
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  3. Gyun Min Lee
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Correspondence to Gyun Min Lee .

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Editors and Affiliations

  1. Dept. Chemical & Biochemical, University College, Dublin, Belfield, Dublin 4, Ireland

    Mohamed Al-Rubeai

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© 2009 Springer Science+Business Media B.V.

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Mohan, C., Kim, YG., Lee, G.M. (2009). Apoptosis and Autophagy Cell Engineering. In: Al-Rubeai, M. (eds) Cell Line Development. Cell Engineering, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2245-5_10

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