Samenvatting
De afgelopen vijftien jaar is er, met behulp van de ontwikkelingsbiologie en weefseltechnologie, een alternatieve therapie uitgewerkt voor het behandelen van geïnfecteerde, zeer immature, blijvende dentitie: de regeneratieve endodontische behandeling (REB). REB berust op vooral chemische desinfectie van het wortelkanaal en drie pijlers: stamcellen, groeifactoren en scaffolds. Het cell homing- en cell based-principe zijn de twee grote concepten van deze behandeling. Het cell based-principe berust op pulpaweefseltechnologie en -transplantatie en heeft tot nog toe vooral in vitro zijn toepassing. Het leidt tot gunstige resultaten voor weefselregeneratie. Vanwege ethische, financiële en infrastructurele beslommeringen, wordt klinisch eerder het cell homing-concept toegepast, wat leidt tot gunstige infectieheling, maar eerder herstel (dan regeneratie) van het pulpadentinecomplex. Omdat er langetermijnresultaten ontbreken en het evidentieniveau van REB nog laag is, is er behoefte aan klinisch, microbieel en translationeel onderzoek.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsNotes
- 1.
ICF-richtlijnen UZ Leuven ‘Formeel geven de kinderen zelf geen toestemming maar moeten wel schriftelijk kunnen instemmen met deelname aan het onderzoek (“instemming” of “assent”, aangeraden vanaf 12 jaar). Uiteraard moeten de ouders steeds hun akkoord geven (“toestemming” of “consent”) voor deelname van hun minderjarige kind aan een studie’ (https://www.uzleuven.be/toetsingscommissie/icf-richtlijnen-voor-het-opstellen-van-een-icf).
Literatuur
Althumairy RI, Teixeira FB, Diogenes A. Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla. J Endod. 2014;40(4):521–5.
Bakland LK, Andreasen JO. Will mineral trioxide aggregate replace calcium hydroxide in treating pulpal and periodontal healing complications subsequent to dental trauma? A review. Dent Traumatol. 2012;28(1):25–32.
Bezgin T, Sonmez H. Review of current concepts of revascularization/revitalization. Dent Traumatol. 2015;31(4):267–73.
Bezgin T, Yilmaz AD, Celik BN, Kolsuz ME, Sonmez H. Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. J Endod. 2015;41(1):36–44.
Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod. 2009;35(10):1343–9.
Chrepa V, Henry MA, Daniel BJ, Diogenes A. Delivery of apical mesenchymal stem cells into root canals of mature teeth. J Dent Res. 2015;94(12):1653–9. [E-pub ahead of print.]
Cvek M. Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha: a retrospective clinical study. Endod Dent Traumatol. 1992;8(2):45–55.
Diogenes A, Henry MA, Teixeira FB. An update on clinical regenerative endodontics. Endod Top. 2013;28:2–23.
Duarte PC, Gomes-Filho JE, Ervolino E, Sundefeld MLMM, Tadahirowayama M, Lodi CS, et al. Histopathological condition of the remaining tissues after endodontic infection of rat immature teeth. J Endod. 2014;40(4):538–42.
Ehrenfest DMD, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3–9.
EzEldeen M, Gorp G van, Dessel J van, Vandermeulen D, Jacobs R. 3-dimensional analysis of regenerative endodontic treatment outcome. J Endod. 2015;41(3):317–24.
Fouad AF, Verma P. Healing after regenerative procedures with and without pulpal infection. J Endod. 2014;40(4 Suppl):S58–64.
Galler KM, D’Souza RN, Hartgerink JD, Schmalz G. Scaffolds for dental pulp tissue engineering. Adv Dent Res. 2011;23(3):333–9.
Galler KM, Eidt A, Schmalz G. Cell-free approaches for dental pulp tissue engineering. J Endod. 2014;40(4 Suppl):S41–5.
Galler KM, Krastl G, Simon S, Gorp G van, Meschi N, Vahedi B, et al. European Society of Endodontology Position Statement: Revitalisation Procedures. Int Endod J. 2016;49(8):717–23.
Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Nat Acad Sci USA. 2000;97(25):13625–30.
Hilkens P, Meschi N, Lambrechts P, Bronckaers A, Lambrichts I. Dental stem cells in pulp regeneration: near future or long road ahead? Stem Cells Dev. 2015;24(14):1610–22.
Huang GT, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod. 2008;34(6):645–51.
Huang GT, Garcia-Godoy F. Missing concepts in de novo pulp regeneration. J Dent Res. 2014;93(8):717–24.
Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol. 2001;17(4):185–7.
Laureys WG, Cuvelier CA, Dermaut LR, Pauw GA de. The critical apical diameter to obtain regeneration of the pulp tissue after tooth transplantation, replantation, or regenerative endodontic treatment. J Endod. 2013;39(6):759–63.
Lin LM, Rosenberg PA. Repair and regeneration in endodontics. Int Endod J. 2011;44(10):889–906.
Mao JJ, Kim SG, Zhou J, Ye L, Cho S, Suzuki T, et al. Regenerative endodontics: barriers and strategies for clinical translation. Dent Clin North Am. 2012;56(3):639–49.
Martin DE, Almeida JF de, Henry MA, Khaing ZZ, Schmidt CE, Teixeira FB, et al. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation. J Endod. 2014;40(1):51–5.
Meschi N, Hilkens P, Lambrichts I, Eynde K van den, Mavridou A, Strijbos O, et al. Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study. Clin Oral Investig. 2016;20(4):807–14.
Moreno-Hidalgo MC, Caleza-Jimenez C, Mendoza-Mendoza A, Iglesias-Linares A. Revascularization of immature permanent teeth with apical periodontitis. Int Endod J. 2014;47(4):321–31.
Nagy MM, Tawfik HE, Hashem AA, Abu-Seida AM. Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod. 2014;40(2):192–8.
Nakashima M, Reddi AH. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol. 2003;21(9):1025–32.
Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 2005;76(12):2205–15.
Ostby BN. The role of the blood clot in endodontic therapy: an experimental histologic study. Acta Odontol Scand. 1961;19:324–53.
Paryani K, Kim SG. Regenerative endodontic treatment of permanent teeth after completion of root development: a report of 2 cases. J Endod. 2013;39(7):929–34.
Phumpatrakom P, Srisuwan T. Regenerative capacity of human dental pulp and apical papilla cells after treatment with a 3-antibiotic mixture. J Endod. 2014;40(3):399–405.
Saoud TM, Zaazou A, Nabil A, Moussa S, Aly HM, Okazaki K, et al. Histological observations of pulpal replacement tissue in immature dog teeth after revascularization of infected pulps. Dent Traumatol. 2015;31(3):243–9.
Torabinejad M, Milan M, Shabahang S, Wright KR, Faras H. Histologic examination of teeth with necrotic pulps and periapical lesions treated with 2 scaffolds: an animal investigation. J Endod. 2015;41(6):846–52.
Vishwakarma A, Sharpe P, Ramalingam M. Stem cell biology and tissue engineering in dental sciences. London, UK: Elsevier; 2015.
Wang J, Zhang H, Zhang W, Huang E, Wang N, Wu N, et al. Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla. Stem Cells Dev. 2014;23(12):1405–16.
Wigler R, Kaufman AY, Lin S, Steinbock N, Hazan-Molina H, Torneck CD. Revascularization: a treatment for permanent teeth with necrotic pulp and incomplete root development. J Endod. 2013;39(3):319–26.
Zhu W, Zhu X, Huang GT, Cheung GS, Dissanayaka WL, Zhang C. Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells. Int Endod J. 2013;46(10):962–70.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 2016 Bohn Stafleu van Loghum
About this chapter
Cite this chapter
Meschi, N., Lambrechts, P. (2016). Regeneratie van pulpaweefsel. In: Aps, J., De Bruyne, M., Jacobs, R., van der Meer, J., Nienhuijs, M., Boxum, S. (eds) Het tandheelkundig jaar 2017. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-1030-2_4
Download citation
DOI: https://doi.org/10.1007/978-90-368-1030-2_4
Published:
Publisher Name: Bohn Stafleu van Loghum, Houten
Print ISBN: 978-90-368-1029-6
Online ISBN: 978-90-368-1030-2
eBook Packages: Dutch language eBook collection